The recognition of the scorpion toxin maurotoxin (MTX) by the voltage-gated potassium
(Kv1) channels, Kv1. 1, Kv1. 2, and Kv1. 3, has been studied by means of Brownian …

Molecular dynamics (MD) simulations are used to examine the binding modes of two
scorpion toxins, margatoxin (MgTx) and hongotoxin (HgTx), to the voltage gated K+ channel …

The 34-residue polypeptide maurotoxin (MTx) isolated from scorpion venoms selectively
inhibits the current of the voltage-gated potassium channel Kv1. 2 by occluding the ion …

The recognition of the scorpion toxin P05 and the small-conductance, calcium-activated
potassium (SK) channels, rsk1, rsk2, and rsk3, has been studied by means of the Brownian …

Based on a homology model of the Kv1. 3 potassium channel, the recognitions of the six
scorpion toxins, viz. agitoxin2, charybdotoxin, kaliotoxin, margatoxin, noxiustoxin, and …

Background Scorpion toxins are invaluable tools for ion channel research and are potential
drugs for human channelopathies. However, it is still an open task to determine the …

Besides classical scorpion toxin–potassium channel binding modes, novel modes remain
unknown. Here, we report a novel binding mode of native toxin BmKTX towards Kv1. 3 …

The association of the scorpion toxin Lq2 and a potassium ion (K+) channel has been
studied using the Brownian dynamics (BD) simulation method. All of the 22 available …

Charybdotoxin, belonging to the group of so-called scorpion toxins, is a short peptide able to
block many voltage-gated potassium channels, such as m Kv1. 3, with high affinity. We use a …

The Ca 2+-activated channel of intermediate-conductance (K Ca 3.1) is a target for
antisickling and immunosuppressant agents. Many small peptides isolated from animal …