Radiation and chemical reactions that give rise to free radicals cause the formation of highly
cytotoxic base propenals, degradation products of DNA. Human glutathione transferases …

Abstract The 4-hydroxyalk-2-enals are established products of lipid peroxidation that are
conjugated with intracellular glutathione. Cytosolic glutathione transferases from rat liver …

Glutathione (GSH) alone detoxifies electrophiles with an effectiveness which depends on
the rate of the reaction and the concentration of GSH. If electrophiles are substrates for GSH …

Glutathione monoesters in which the carboxyl group of the glycine residue is esterified were
previously found, in contrast to glutathione itself, to be effectively transported into various …

Margareta Warholm, Claes Guthenberg, and Bengt Mannervik* abstract: Glutathione
transferases with basic isoelectric points are present in the cytosol of all human livers investi …

Glutathione monoesters in which the glycine carboxyl g group is esterified are effective
cellular glutathione delivery agents because they are readily transported into cells and are …

The contributionof chemistry to toxicological re-search has increased dramatically over the
past 15-20 years. This development has been due in large measure to the growing …

Materials and Methods Chemicals. Benzo [a] pyrene 4, 5-oxide was obtained from the
Cancer Research Program of the National Cancer In-stitute, Division of Cancer Cause and …

1. Heat-inactivation experiments, ammonium sulphate-fractionation studies, enzyme-
inhibition studies with S-(αβ-diethoxycarbonylethyl) glutathione, and evidence from the …

One of Eric Boyland's many important contributions to our insight into the metabolism of
xenobiotics has been his recognition of the importance of detoxication by glutathione (GSH) …