Abstract Thrombospondin (TSP)‑1 and TSP‑2 are matricellular proteins in the extracellular
matrix (ECM), which serve a significant role in the pathological processes of various …

Thrombospondins (TSPs) represent extracellular matrix (ECM) proteins belonging to the
TSP family that comprises five members. All TSPs have a complex multidomain structure that …

Cardiovascular diseases (CVDs) remain a leading cause of morbidity and mortality in the
developed world and are becoming increasingly prevalent in the developing world …

Thrombospondins (TSPs) are multidomain, secreted proteins that associate with cell
surfaces and extracellular matrix. In mammals, there is a large body of data on functional …

The thrombospondin (TSP) family consists of five multimeric, multidomain calcium‐binding
glycoproteins that act as regulators of cell–cell and cell–matrix associations as well as …

Cardiac remodeling after myocardial injury involves inflammation, angiogenesis, left
ventricular hypertrophy and matrix remodeling. Thrombospondins (TSPs) belong to the …

Abstract Thrombospondin‐1 (TSP‐1), a matricellular protein and one of the first endogenous
anti‐angiogenic molecules identified, has long been considered a potent modulator of …

Abstract Thrombospondin-4 (TSP-4) belongs to the thrombospondin protein family that
consists of five highly homologous members. A number of novel functions have been …

Since the discovery of thrombospondin (TSP)-1 thirty years ago, 1 this matricellular
(regulating cell–matrix interaction) protein has been a focal point for attention of …

Abstract Introduction The thrombospondins (TSPs) are matricellular proteins that exert
multifunctional effects by binding cytokines, cell-surface receptors and other proteins. TSPs …