Nearly all studies of angiogenesis have focused on uni-family ligand-receptor binding, eg,
VEGFs bind to VEGF receptors, PDGFs bind to PDGF receptors, etc. The discovery of VEGF …

Computational modeling of angiogenesis is limited by a lack of experimental data on
angiogenic receptor levels. Recent receptor profiling quantified vascular endothelial growth …

Angiogenesis is a highly regulated process orchestrated, in large part, by the vascular
endothelial growth factor-A (VEGF-A) system of ligands and receptors. Considerable effort …

The simultaneous targeting of both endothelial cells and pericytes via inhibition of VEGF
receptor (VEGFR) and PDGFβ receptor (PDGFRβ) signaling, respectively, has been …

The ability to control vascular endothelial growth factor (VEGF) signaling offers promising
therapeutic potential for vascular diseases and cancer. Despite this promise, VEGF-targeted …

Matrix-binding isoforms and non-matrix-binding isoforms of vascular endothelial growth
factor (VEGF) are both capable of stimulating vascular remodeling, but the resulting blood …

Vascular endothelial growth factor (VEGF) is a potent cytokine involved in the induction of
neovascularization. Secreted as a cysteine-linked dimer, it has two binding sites at opposite …

The mechanisms that allow cells to bypass anti–vascular endothelial growth factor A
(VEGFA) therapy remain poorly understood. Here we use zebrafish to investigate this …

The splice isoforms of vascular endothelial growth A (VEGF) each have different affinities for
the extracellular matrix (ECM) and the coreceptor NRP1, which leads to distinct vascular …

Vascular endothelial growth factors (VEGFs) bind to membrane receptors on a wide variety
of cells to regulate diverse biological responses. The VEGF-A family member promotes …