Astrocyte morphogenesis is dependent on BDNF signaling via astrocytic TrkB. T1

LM Holt, RD Hernandez, NL Pacheco, B Torres Ceja… - Elife, 2019 - elifesciences.org
Brain-derived neurotrophic factor (BDNF) is a critical growth factor involved in the maturation
of the CNS, including neuronal morphology and synapse refinement. Herein, we …

Truncated tyrosine kinase B brain‐derived neurotrophic factor receptor directs cortical neural stem cells to a glial cell fate by a novel signaling mechanism

A Cheng, T Coksaygan, H Tang, R Khatri… - Journal of …, 2007 - Wiley Online Library
During development of the mammalian cerebral cortex neural stem cells (NSC) first
generate neurons and subsequently produce glial cells. The mechanism (s) responsible for …

The dynamic distribution of TrkB receptors before, during, and after synapse formation between cortical neurons

RA Gomes, C Hampton, F El-Sabeawy… - Journal of …, 2006 - Soc Neuroscience
Although brain-derived neurotrophic factor (BDNF) potently regulates neuronal connectivity
in the developing CNS, the mechanism by which BDNF influences the formation and/or …

Postsynaptic BDNF‐TrkB signaling in synapse maturation, plasticity, and disease

A Yoshii, M Constantine‐Paton - Developmental neurobiology, 2010 - Wiley Online Library
Brain‐derived neurotrophic factor (BDNF) is a prototypic neurotrophin that regulates diverse
developmental events from the selection of neural progenitors to the terminal dendritic …

[HTML][HTML] Brain-derived neurotrophic factor (BDNF) promotes molecular polarization and differentiation of immature neuroblastoma cells into definitive neurons

L Hromadkova, D Bezdekova, J Pala… - … et Biophysica Acta (BBA …, 2020 - Elsevier
Throughout development, neuronal progenitors undergo complex transformation into
polarized nerve cells, warranting the directional flow of information in the neural grid. The …

Cellular and molecular mechanisms regulating neuronal growth by brain‐derived neurotrophic factor

A Gonzalez, G Moya‐Alvarado… - …, 2016 - Wiley Online Library
Brain‐derived neurotrophic factor (BDNF) and its receptors TrkB and p75 regulate dendritic
and axonal growth during development and maintenance of the mature nervous system; …

Differential effects of transient and sustained activation of BDNF‐TrkB signaling

W Guo, G Nagappan, B Lu - Developmental neurobiology, 2018 - Wiley Online Library
Brain‐derived neurotrophic factor (BDNF) serves a pleiotropic role in the central nervous
system, ranging from promoting neuronal survival and differentiation during development …

Activity-dependent modulation of the BDNF receptor TrkB: mechanisms and implications

G Nagappan, B Lu - Trends in neurosciences, 2005 - cell.com
Although brain-derived neurotrophic factor (BDNF) has emerged as a key regulator of
activity-dependent synaptic plasticity, a conceptually challenging question is how this …

Dynamic expression of TrkB receptor protein on proliferating and maturing cells in the adult mouse dentate gyrus

MH Donovan, M Yamaguchi, AJ Eisch - Hippocampus, 2008 - Wiley Online Library
Brain‐derived neurotrophic factor (BDNF) is implicated in the regulation of adult
hippocampal neurogenesis, presumably via its primary receptor, TrkB. However, controversy …

Regulation of TRKB surface expression by brain-derived neurotrophic factor and truncated TRKB isoforms

A Haapasalo, I Sipola, K Larsson, KEO Åkerman… - Journal of Biological …, 2002 - ASBMB
Brain-derived neurotrophic factor (BDNF) signaling through its receptor TRKB modulates
survival, differentiation, and activity of neurons. BDNF activates TRKB on the cell surface …