Mass spectrometry imaging (MSI) has become an important analytical tool for the label‐free
chemical imaging of diverse molecules in biological specimens. This minireview surveys …

Mass spectrometry imaging (MSI) is a comprehensive tool for the analysis of a wide range of
biomolecules. The mainstream method for molecular MSI is matrix‐assisted laser desorption …

Imaging of specific small molecules is particularly challenging using conventional optical
microscopy techniques. This has led to the development of alternative imaging modalities …

Endogenous small molecules play important roles in biological processes and are closely
related to the occurrence and development of many diseases. Profiling of spatial distribution …

Matrix‐assisted laser desorption/ionization mass spectrometry (MALDI‐MS) is widely used
in the biomedical field for the label‐free analysis of molecules such as drugs, lipids …

Mass spectrometry imaging (MSI) enables simultaneous spatial mapping for diverse
molecules in biological tissues. Matrix‐assisted laser desorption ionization (MALDI) mass …

Highlights•New MALDI matrices and new matrix deposition techniques have advanced MS
imaging.•Multiplexed MALDI-MSI can image hundreds to more than 1000 molecular …

Laser desorption ionization mass spectrometry (LDI-MS) has been developed to be an
essential tool for the analysis and identification of a large variety of species, ranging from …

Today, two-dimensional mass spectrometry analysis of biological tissues by means of a
technique called mass imaging, mass spectrometry imaging (MSI), or imaging mass …

Few matrices have the potential to be universally applicable for imaging vast endogenous
compounds ranging from micro to macromolecules. In this article, we present hydralazine …