Even with the best available care, at least 25% of leg ulcers and foot ulcers are not fully
healed after 6 months of treatment. This review summarizes the pathophysiological features …

Lower extremity ulcerations affect up to 49 million people annually worldwide with a
cumulative lifetime risk of 1.0% to 1.8%, causing significant morbidity, mortality, and cost to …

Chronic lower extremity ulcers are a significant burden on patients and health care systems
worldwide. Although relatively common, these wounds can be difficult to treat and present a …

The treatment of leg ulcers is a common and sometimes difficult problem. They can be costly
to treat and are associated with loss of working capacity and sometimes significant …

Chronic wounds are those that do not progress through a normal, orderly, and timely
sequence of repair. They are common and are often incorrectly treated. The morbidity and …

Leg ulcer is a leading cause of morbidity among older subjects, especially women in the
Western world. About 400 years BC, Hippocrates wrote,“In case of an ulcer, it is not …

Chronic leg ulcer is defined as a defect in the skin below the level of knee persisting for
more than six weeks and shows no tendency to heal after three or more months. Chronic …

Chronic wounds of the lower extremities are occurring with increasing prevalence. They
affect millions of individuals annually, representing both a significant health risk and a large …

Lower extremity complications in persons with diabetes have become an increasingly
significant public health concern in both the developed and developing world. These …

When treating diabetic foot ulcers it is important to be aware of the natural history of the
diabetic foot, which can be divided into five stages: stage 1, a normal foot; stage 2, a high …