ARID1A orchestrates SWI/SNF-mediated sequential binding of transcription factors with ARID1A loss driving pre-memory B cell fate and lymphomagenesis
ARID1A, a subunit of the canonical BAF nucleosome remodeling complex, is commonly
mutated in lymphomas. We show that ARID1A orchestrates B cell fate during the germinal …
mutated in lymphomas. We show that ARID1A orchestrates B cell fate during the germinal …
Chromatin accessibility underlies synthetic lethality of SWI/SNF subunits in ARID1A-mutant cancers
TWR Kelso, DK Porter, ML Amaral, MN Shokhirev… - Elife, 2017 - elifesciences.org
ARID1A, a subunit of the SWI/SNF chromatin remodeling complex, is frequently mutated in
cancer. Deficiency in its homolog ARID1B is synthetically lethal with ARID1A mutation …
cancer. Deficiency in its homolog ARID1B is synthetically lethal with ARID1A mutation …
ARID1B is a specific vulnerability in ARID1A-mutant cancers
Recent studies have revealed that ARID1A, encoding AT-rich interactive domain 1A (SWI-
like), is frequently mutated across a variety of human cancers and also has bona fide tumor …
like), is frequently mutated across a variety of human cancers and also has bona fide tumor …
Epigenetic driver mutations in ARID1A shape cancer immune phenotype and immunotherapy
Whether mutations in cancer driver genes directly affect cancer immune phenotype and T
cell immunity remains a standing question. ARID1A is a core member of the polymorphic …
cell immunity remains a standing question. ARID1A is a core member of the polymorphic …
ARID1A loss in cancer: towards a mechanistic understanding
R Mathur - Pharmacology & therapeutics, 2018 - Elsevier
Genes encoding subunits of SWI/SNF chromatin remodeling complexes are collectively
mutated in 20% of all human cancers. ARID1A is the SWI/SNF subunit gene that is most …
mutated in 20% of all human cancers. ARID1A is the SWI/SNF subunit gene that is most …
ARID1A loss in neuroblastoma promotes the adrenergic-to-mesenchymal transition by regulating enhancer-mediated gene expression
Mutations in genes encoding SWI/SNF chromatin remodeling complexes are found in
approximately 20% of all human cancers, with ARID1A being the most frequently mutated …
approximately 20% of all human cancers, with ARID1A being the most frequently mutated …
Chromatin remodeling mediated by ARID1A is indispensable for normal hematopoiesis in mice
Precise regulation of chromatin architecture is vital to physiological processes including
hematopoiesis. ARID1A is a core component of the mammalian SWI/SNF complex, which is …
hematopoiesis. ARID1A is a core component of the mammalian SWI/SNF complex, which is …
The Role of ARID1A in Tumors: Tumor Initiation or Tumor Suppression?
S Xu, C Tang - Frontiers in Oncology, 2021 - frontiersin.org
Genes encoding subunits of SWItch/Sucrose Non-Fermenting (SWI/SNF) chromatin
remodeling complexes are collectively mutated in 20% of all human cancers, among which …
remodeling complexes are collectively mutated in 20% of all human cancers, among which …
ARID1A loss impairs enhancer-mediated gene regulation and drives colon cancer in mice
Genes encoding subunits of SWI/SNF (BAF) chromatin-remodeling complexes are
collectively mutated in∼ 20% of all human cancers,. Although ARID1A is the most frequent …
collectively mutated in∼ 20% of all human cancers,. Although ARID1A is the most frequent …
ARID1A deficiency promotes mutability and potentiates therapeutic antitumor immunity unleashed by immune checkpoint blockade
Abstract ARID1A (the AT-rich interaction domain 1A, also known as BAF250a) is one of the
most commonly mutated genes in cancer,. The majority of ARID1A mutations are inactivating …
most commonly mutated genes in cancer,. The majority of ARID1A mutations are inactivating …