The biphasic display of paw-flinch behavior in the rat after injection of formalin into the
dorsum of the hind paw is used for the screening of anti-hyperalgesic agents. Described and …

Administration of 5% formalin into the rat or guinea pig hind paw evokes two spontaneous
responses: flinching/shaking and licking/biting of the injected paw. The temporal and …

The formalin test was originally developed by Dubuisson and Dennis (1977), and has since
been extensively used to assess pain-related responses. Rats and mice are the most …

A novel, computer-driven, dynamic-force detector was validated for use in measuring the
formalin-induced agitation response. Intraplantar administration of formalin (0.25–5%) …

Methods All experiments utilized male Sprague-Dawley rats (Harlan Sprague Dawley Inc.,
Indianapolis, IN), weighing from 175 to 200 g. All procedures were approved by the …

The formalin tonic pain test has recently been adapted for use in mice. We have observed
two problems with this procedure. First, compared to a vehicle control group, the majority of …

Opioids are effective topical analgesics in the radiant heat tailflick assay and display
synergistic interactions with a number of other classes of drugs. To determine whether these …

The formalin test is increasingly used as a model of injury-produced pain but there is no
generally accepted method of pain rating. To examine the properties of various pain rating …

A modification of the formalin test appropriate for testing of mice is described. Formalin 1 or
5% was injected into the dorsal surface of a hindpaw, and the time the animal spent licking …

The formalin test is a well‐established model for assessing nociceptive processes and
analgesic drug effects. Previous studies have provided statistical validation of optimal …