[HTML][HTML] The macrophage-osteoclast axis in osteoimmunity and osteo-related diseases

Y Yao, X Cai, F Ren, Y Ye, F Wang, C Zheng… - Frontiers in …, 2021 - frontiersin.org
Osteoimmunity is involved in regulating the balance of bone remodeling and resorption, and
is essential for maintaining normal bone morphology. The interaction between immune cells …

[HTML][HTML] Macrophage-osteoclast associations: origin, polarization, and subgroups

Y Sun, J Li, X Xie, F Gu, Z Sui, K Zhang… - Frontiers in …, 2021 - frontiersin.org
Cellular associations in the bone microenvironment are involved in modulating the balance
between bone remodeling and resorption, which is necessary for maintaining a normal bone …

New immune connections in osteoclast formation

H Takayanagi - Annals of the New York Academy of Sciences, 2010 - Wiley Online Library
Osteoimmunology is an interdisciplinary research field that investigates the interplay of the
skeletal and immune systems at the molecular level. The interaction between immune cells …

Macrophage polarization and the regulation of bone immunity in bone homeostasis

K Hu, Z Shang, X Yang, Y Zhang… - Journal of Inflammation …, 2023 - Taylor & Francis
Bone homeostasis is a dynamic equilibrium state of bone formation and absorption,
ensuring skeletal development and repair. Bone immunity encompasses all aspects of the …

[HTML][HTML] The role of immune cells in modulating chronic inflammation and osteonecrosis

J Zheng, Z Yao, L Xue, D Wang, Z Tan - Frontiers in immunology, 2022 - frontiersin.org
Osteonecrosis occurs when, under continuous stimulation by adverse factors such as
glucocorticoids or alcohol, the death of local bone and marrow cells leads to abnormal …

[HTML][HTML] Immune function and diversity of osteoclasts in normal and pathological conditions

MB Madel, L Ibáñez, A Wakkach, TJ De Vries… - Frontiers in …, 2019 - frontiersin.org
Osteoclasts (OCLs) are key players in controlling bone remodeling. Modifications in their
differentiation or bone resorbing activity are associated with a number of pathologies …

[HTML][HTML] The effect of cytokines on osteoblasts and osteoclasts in bone remodeling in osteoporosis: A review

J Xu, L Yu, F Liu, L Wan, Z Deng - Frontiers in Immunology, 2023 - frontiersin.org
The complicated connections and cross talk between the skeletal system and the immune
system are attracting more attention, which is developing into the field of Osteoimmunology …

Cytokine‐mediated bone destruction in rheumatoid arthritis

SM Jung, KW Kim, CW Yang… - Journal of immunology …, 2014 - Wiley Online Library
Bone homeostasis, which involves formation and resorption, is an important process for
maintaining adequate bone mass in humans. Rheumatoid arthritis (RA) is an autoimmune …

The interplay between the bone and the immune system

G Mori, PD′ Amelio, R Faccio… - Journal of Immunology …, 2013 - Wiley Online Library
In the last two decades, numerous scientists have highlighted the interactions between bone
and immune cells as well as their overlapping regulatory mechanisms. For example …

[HTML][HTML] Macrophages and bone inflammation

Q Gu, H Yang, Q Shi - Journal of orthopaedic translation, 2017 - Elsevier
Bone metabolism is tightly regulated by the immune system. Accelerated bone destruction is
observed in many bone diseases, such as rheumatoid arthritis, fracture, and particle …