Abstract Background Cyclin-dependent kinase-2 (CDK-2) is an important regulatory factor in
the G1/S phase transition. CDK-2 targeting has been shown to suppress the viability of …

Isolongifolanone is a high value-added sustainable natural product. Recent studies have
demonstrated that isolongifolanone possesses anticancer activities. In this study, a series of …

Glioblastoma (GBM) is a deadly brain tumor characterized by signaling dysregulation and
aberrant cell cycle control. The CDK4/6-Rb axis is dysregulated in approximately 80% of all …

Glioblastoma multiforme (GBM) is the most common and deadliest of malignant brain tumors
in adults. Disease development is associated with dysregulation of the cyclin D-CDK4/6 …

Cyclin-dependent kinase 1 (CDK1) plays an indispensable role in the whole cell cycle. It has
become a new target for cancer therapy. According to the binding mode of a pan-CDK …

Glioblastoma (GBM) is known for its aggressive nature and poor prognosis, with currently no
effective treatment available. Research has shown that introducing fluorinated functional …

Glioma is the fast-growing, aggressive, and prevalent brain cancer with a great level of
morbidity and mortality. Current therapy is usually found insufficient for glioma treatment. In …

Background Ligustilide (LIG) and n-butylphthalide (NBP) have neuroprotective effects in
cerebral ischemia; however, their roles in gliomas are not well-known. This study aimed to …

Glioma, particularly its most malignant form, glioblastoma multiforme (GBM), is the most
common and aggressive malignant central nervous system tumor. The drawbacks of the …

Glioblastoma Multiforme (GBM) continues to demand improved chemotherapeutic solutions.
In order to discover novel chemotherapeutic agents for GBM, we identified novel …