[HTML][HTML] The clinical implications of nocebo effects for biosimilar therapy

L Colloca, R Panaccione, TK Murphy - Frontiers in pharmacology, 2019 - frontiersin.org
Nocebo effects encompass negative responses to inert interventions in the research setting
and negative outcomes with active treatments in the clinical research or practice settings …

[HTML][HTML] Treatment outcomes with biosimilars: be aware of the nocebo effect

MF Rezk, B Pieper - Rheumatology and therapy, 2017 - Springer
Over the years, biologic agents have proven their importance in the management of chronic
autoimmune diseases, such as rheumatoid arthritis, psoriasis, and inflammatory bowel …

[HTML][HTML] To see or NOsee: the debate on the nocebo effect and optimizing the use of biosimilars

MF Rezk, B Pieper - Advances in therapy, 2018 - Springer
Abstract In addition to the general clinical benefit offered, biosimilars may not only generate
savings for healthcare budgets but also improve patient access to biologic products. Since …

The nocebo effect: a clinical challenge in the era of biosimilars

L Pouillon, M Socha, B Demore, N Thilly… - Expert review of …, 2018 - Taylor & Francis
Introduction: The nocebo effect is defined as a negative effect of a pharmacological or non-
pharmacological medical treatment that is induced by patients' expectations, and that is …

The biosimilar nocebo effect? A systematic review of double-blinded versus open-label studies

JS Odinet, CE Day, JL Cruz, GA Heindel - Journal of managed care & …, 2018 - jmcp.org
BACKGROUND: Several authors have hypothesized that adverse drug events (ADEs) upon
switching from reference biologics to biosimilar products are related to the nocebo effect …

[HTML][HTML] Nonmedical switching from originators to biosimilars: does the nocebo effect explain treatment failures and adverse events in rheumatology and …

R Fleischmann, V Jairath, E Mysler, D Nicholls… - Rheumatology and …, 2020 - Springer
The act of nonmedical switching, defined as switching stable patients who are generally
doing well with their current therapy from an originator biologic to its biosimilar, has been …

[HTML][HTML] Non-pharmacological effects in switching medication: the nocebo effect in switching from originator to biosimilar agent

LE Kristensen, R Alten, L Puig, S Philipp, TK Kvien… - BioDrugs, 2018 - Springer
The nocebo effect is defined as the incitement or the worsening of symptoms induced by any
negative attitude from non-pharmacological therapeutic intervention, sham, or active …

[HTML][HTML] European stakeholder learnings regarding biosimilars: part II—improving biosimilar use in clinical practice

L Barbier, S Simoens, AG Vulto, I Huys - BioDrugs, 2020 - Springer
Background Despite the benefits biosimilars offer in terms of cost savings and patient
access, healthcare professionals and patients have been reluctant to use them. Next to …

Nocebos in rheumatology: emerging concepts and their implications for clinical practice

E Kravvariti, GD Kitas, DD Mitsikostas… - Nature reviews …, 2018 - nature.com
Nocebo effects are noxious reactions to therapeutic interventions that occur because of
negative expectations of the patient. In the past decade, neurobiological data have revealed …

Treatment journey in rheumatoid arthritis with biosimilars: from better access to good disease control through cost savings and prevention of nocebo effects

JS Smolen, R Caporali, T Doerner, B Fautrel… - RMD open, 2021 - rmdopen.bmj.com
Early diagnosis and treatment of rheumatoid arthritis (RA) are of critical importance to halt
the progression of the disease. Optimal use of advanced imaging techniques or biomarkers …