Protein misfolding and aggregation, a key contributor to the progression of numerous
neurodegenerative diseases, results in functional deficiencies and the creation of harmful …

Misfolding and aggregation of proteins is a common thread linking a number of important
human health problems. The misfolded and aggregated proteins are inducers of cellular …

Newly synthesised proteins need to fold, often to intricate and close-packed structures, in
order to function. The underlying mechanism by which this complex process takes place …

Protein misfolding is the underlying cause of many highly debilitating disorders ranging from
Alzheimer's Disease to Cystic Fibrosis. Great strides have been made recently in …

Protein folding is a complex, multisystem process characterized by heavy molecular and
cellular footprints. Chaperone machinery enables proper protein folding and stable …

A common pathogenic mechanism shared by diverse neurodegenerative disorders, like
Alzheimer's disease, Parkinson's disease, Huntington's disease and transmissible …

Protein misfolding disorders, including the neurodegenerative conditions Alzheimer's
disease (AD) and Parkinson's disease (PD) represent one of the major medical challenges …

Conspectus Protein aggregation is a biological phenomenon in which aberrantly processed
or mutant proteins misfold and assemble into a variety of insoluble aggregates. Decades of …

Protein aggregation is widely considered to be a nonspecific coalescence of misfolded
proteins, driven by interactions between solvent-exposed hydrophobic surfaces that are …

Protein aggregation is a central hallmark of many neurodegenerative disorders, but the
relationship of aggregate structural diversity to the resultant cellular cytotoxicity and …