Current treatments for clear cell renal cell cancer (ccRCC) are insufficient because two-
thirds of patients with metastases progress within two years. Here we report the identification …

Clear cell renal cell carcinoma (ccRCC) is the most common type of kidney cancer in adults.
When ccRCC is localized to the kidney, surgical resection or ablation of the tumor is often …

Abstract Background Cancer stem cells (CSCs) are correlated with the initiation,
chemoresistance and relapse of tumors. Notch pathway has been reported to function in …

There are considerable differences in tumour biology between adult and paediatric cancers.
The existence of cancer initiating cells/cancer stem cells (CIC/CSC) in paediatric solid …

Metastasis remains the main reason for renal cell carcinoma (RCC)–associated mortality.
Tyrosine kinase inhibitors (TKI) impart clinical benefit for most patients with RCC, but the …

The clear cell renal cell carcinoma (ccRCC) microenvironment consists of many different cell
types and structural components that play critical roles in cancer progression and drug …

Clear cell renal cell carcinoma (ccRCC) is the third type of urologic cancer. At time of
diagnosis, 30% of cases are metastatic with no effect of chemotherapy or radiotherapy …

Background Kidney cancer is one of the most common solid tumors. The advancement of
human kidney cancer research and treatment has been hindered by a lack of research …

Characterised by high intra‐and inter‐tumor heterogeneity, metastatic renal cell carcinoma
(RCC) is resistant to chemo‐and radiotherapy. Therefore, the development of new …

In recent years, cancer stem cells (CSCs)/tumor initiating cells (TICs) have been identified
inside different tumors. However, currently used anti-cancer therapies are mostly directed …