Selective autophagy of mitochondria, known as mitophagy, is an important mitochondrial
quality control mechanism that eliminates damaged mitochondria. Mitophagy also mediates …

Mitochondrial quality control is central for maintaining a healthy population of mitochondria.
Two Parkinson's disease genes, mitochondrial kinase PINK1 and ubiquitin ligase Parkin …

Mitochondria are the powerhouses for the cell, consuming oxygen to generate sufficient
energy for the maintenance of normal cellular processes. However, a deleterious …

Selective autophagy of mitochondria, or mitophagy, refers to the specific removal and
degradation of damaged or surplus mitochondria via targeting to the lysosome for …

Macroautophagy is a cellular process by which cytosolic components and organelles are
degraded in double-membrane bound structures upon fusion with lysosomes. A pathway for …

Parkinson's disease (PD) is one of the most prevalent neurodegenerative disorders.
Pathologically, it is characterized by the loss of dopaminergic neurons in the substantia …

Highlights•PINK1 and Parkin are implicated in regulating mitophagy but in vivo evidence is
conflicting.•Results support a complex and subtle process of mitochondrial quality …

Neurons are highly specialised cells with a large bioenergetic demand, and so require a
healthy mitochondrial network to function effectively. This network is compromised in many …

Two Parkinson's disease (PD)-associated proteins, the mitochondrial kinase PINK1 and the
E3-ubiquitin (Ub) ligase PARKIN, are central to mitochondrial quality control. In this pathway …

Mutations in Parkin or PINK1 are the most common cause of recessive familial
parkinsonism. Recent studies suggest that PINK1 and Parkin form a mitochondria quality …