While depression and chronic pain are frequently comorbid, underlying neuronal circuits
and their psychopathological relevance remain poorly defined. Here we show in mice that …

Comorbid depressive symptoms (CDS) in chronic pain are a common health problem, but
the neural circuit mechanisms underlying these symptoms remain unclear. Here we identify …

Pain perception is essential for survival and can be amplified or suppressed by
expectations, experiences, and context. The neural mechanisms underlying bidirectional …

While comorbid pain in depression (CP) occurs at a high rate worldwide, the neural
connections underlying the core symptoms of CP have yet to be elucidated. Here, we define …

Anxiety disorders are complex diseases, and often co-occur with depression. It is as yet
unclear if a common neural circuit controls anxiety-related behaviors in both anxiety-alone …

The amygdala is important for processing emotion, including negative emotion such as
anxiety and depression induced by chronic pain. Although remarkable progress has been …

Background Depression is frequently associated with chronic pain or chronic stress. Among
cortical areas, the anterior cingulate cortex (ACC, areas 24a and 24b) appears to be …

Pain involves an intrinsically dynamic connectome characterized by fluctuating spontaneous
brain activity and continuous neuroplastic changes of relevant circuits. Activity in the …

Chronic pain is associated with anxio-depressive comorbidities, but the neuroanatomical
substrates remain unknown. A specific serotonergic pathway from the dorsal raphe nucleus …

Depression symptoms are often found in patients suffering from chronic pain, a
phenomenon that is yet to be understood mechanistically. Here, we systematically …