Approximately half of the patients with signs and symptoms of heart failure have a left
ventricular ejection fraction that is not markedly abnormal. Despite the historically initial …

Pharmacologic clinical trials for heart failure with preserved ejection fraction have been
largely unsuccessful as compared to those for heart failure with reduced ejection fraction …

By definition, patients with heart failure and preserved ejection fraction are characterized by
a normal or near-normal left ventricular ejection fraction, but marked heterogeneity in the …

Heart failure is a global public health problem that affects more than 26 million people
worldwide. The global burden of heart failure is growing and is expected to increase …

The number of persons with heart failure has continued to rise over the last several years.
Approximately one-half of those living with heart failure have heart failure with preserved …

The clinical syndrome comprising heart failure (HF) symptoms but with a left ventricular
ejection fraction (EF) that is not diminished, eg, HF with preserved EF, is increasingly the …

Heart failure patients are classified by ejection fraction (EF) into distinct groups: heart failure
with preserved ejection fraction (HFpEF) or heart failure with reduced ejection fraction …

The management of heart failure with reduced ejection fraction (HF-REF) has improved
significantly over the last two decades. In contrast, little or no progress has been made in …

Among patients with heart failure with reduced ejection fraction, investigators have
repeatedly identified a subgroup whose left ventricular ejection fraction and structural …

It is estimated that half of all patients with heart failure (HF) have HF with preserved ejection
fraction (HFpEF). Yet this form of HF remains a diagnostic and therapeutic challenge …