Organ-specific endothelial cell differentiation and impact of microenvironmental cues on endothelial heterogeneity

L Gifre-Renom, M Daems, A Luttun… - International journal of …, 2022 - mdpi.com
Endothelial cells throughout the body are heterogeneous, and this is tightly linked to the
specific functions of organs and tissues. Heterogeneity is already determined from …

Organ/tissue-specific vascular endothelial cell heterogeneity in health and disease

T Minami, M Muramatsu, T Kume - Biological and Pharmaceutical …, 2019 - jstage.jst.go.jp
The vascular system forms the largest surface in our body, serving as a critical interface
between blood circulation and our diverse organ/tissue environments. Thus, the vascular …

Endothelial cells and organ function: applications and implications of understanding unique and reciprocal remodelling

M Reiterer, CM Branco - The FEBS Journal, 2020 - Wiley Online Library
The microvasculature is a heterogeneous, dynamic and versatile component of the systemic
circulation, with a unique ability to locally self‐regulate and to respond to organ demand and …

Molecular signatures of tissue-specific microvascular endothelial cell heterogeneity in organ maintenance and regeneration

DJ Nolan, M Ginsberg, E Israely, B Palikuqi… - Developmental cell, 2013 - cell.com
Microvascular endothelial cells (ECs) within different tissues are endowed with distinct but
as yet unrecognized structural, phenotypic, and functional attributes. We devised EC …

Endothelial heterogeneity in development and wound healing

DB Gurevich, DT David, A Sundararaman, J Patel - Cells, 2021 - mdpi.com
The vasculature is comprised of endothelial cells that are heterogeneous in nature. From
tissue resident progenitors to mature differentiated endothelial cells, the diversity of these …

Vascular endothelial cell development and diversity

E Trimm, K Red-Horse - Nature Reviews Cardiology, 2023 - nature.com
Vascular endothelial cells form the inner layer of blood vessels where they have a key role
in the development and maintenance of the functional circulatory system and provide …

Vascular endothelial cell biology: an update

A Krüger-Genge, A Blocki, RP Franke… - International journal of …, 2019 - mdpi.com
The vascular endothelium, a monolayer of endothelial cells (EC), constitutes the inner
cellular lining of arteries, veins and capillaries and therefore is in direct contact with the …

Endothelial cell plasticity at the single-cell level

A Pasut, LM Becker, A Cuypers, P Carmeliet - Angiogenesis, 2021 - Springer
The vascular endothelium is characterized by a remarkable level of plasticity, which is the
driving force not only of physiological repair/remodeling of adult tissues but also of …

Blood flow forces in shaping the vascular system: a focus on endothelial cell behavior

P Campinho, A Vilfan, J Vermot - Frontiers in physiology, 2020 - frontiersin.org
The endothelium is the cell monolayer that lines the interior of the blood vessels separating
the vessel lumen where blood circulates, from the surrounding tissues. During embryonic …

Single cell analysis of endothelial cells identified organ-specific molecular signatures and heart-specific cell populations and molecular features

W Feng, L Chen, PK Nguyen, SM Wu… - Frontiers in cardiovascular …, 2019 - frontiersin.org
Endothelial cells line the inner surface of vasculature and play an important role in normal
physiology and disease progression. Although most tissue is known to have a …