Autophagy modulation by viral infections influences tumor development

L Leonardi, S Sibéril, M Alifano, I Cremer… - Frontiers in …, 2021 - frontiersin.org
Autophagy is a self-degradative process important for balancing cellular homeostasis at
critical times in development and/or in response to nutrient stress. This is particularly …

Autophagy in viral development and progression of cancer

A Suares, MV Medina, O Coso - Frontiers in oncology, 2021 - frontiersin.org
Autophagy is a complex degradative process by which eukaryotic cells capture cytoplasmic
components for subsequent degradation through lysosomal hydrolases. Although this …

[HTML][HTML] Modulation of autophagy-like processes by tumor viruses

HID Mack, K Munger - Cells, 2012 - mdpi.com
Autophagy is an intracellular degradation pathway for long-lived proteins and organelles.
This process is activated above basal levels upon cell intrinsic or environmental stress and …

Regulation of autophagy in cells infected with oncogenic human viruses and its impact on cancer development

T Vescovo, B Pagni, M Piacentini, GM Fimia… - Frontiers in cell and …, 2020 - frontiersin.org
About 20% of total cancer cases are associated to infections. To date, seven human viruses
have been directly linked to cancer development: high-risk human papillomaviruses …

Autophagy in tumor immunity and viral-based immunotherapeutic approaches in cancer

A Zahedi-Amiri, K Malone, ST Beug, T Alain… - Cells, 2021 - mdpi.com
Autophagy is a fundamental catabolic process essential for the maintenance of cellular and
tissue homeostasis, as well as directly contributing to the control of invading pathogens …

Molecular mechanisms of autophagy in cancer development, progression, and therapy

VAM Vitto, S Bianchin, AA Zolondick, G Pellielo… - Biomedicines, 2022 - mdpi.com
Autophagy is an evolutionarily conserved and tightly regulated process that plays an
important role in maintaining cellular homeostasis. It involves regulation of various genes …

Autophagy regulators in cancer

J Zhang, Q Xiang, M Wu, YZ Lao, YF Xian… - International Journal of …, 2023 - mdpi.com
Autophagy plays a complex impact role in tumor initiation and development. It serves as a
double-edged sword by supporting cell survival in certain situations while also triggering …

The evolving, multifaceted roles of autophagy in cancer

J Liu, J Debnath - Advances in cancer research, 2016 - Elsevier
Autophagy is a lysosomal degradation process crucial for adaptation to stress and cellular
homeostasis. In cancer, autophagy has been demonstrated to serve multifaceted roles in …

The double-edge sword of autophagy in cancer: from tumor suppression to pro-tumor activity

R Chavez-Dominguez, M Perez-Medina… - Frontiers in …, 2020 - frontiersin.org
During tumorigenesis, cancer cells are exposed to a wide variety of intrinsic and extrinsic
stresses that challenge homeostasis and growth. Cancer cells display activation of distinct …

Targeting autophagy to enhance oncolytic virus-based cancer therapy

S Meng, J Xu, Y Wu, C Ding - Expert opinion on biological therapy, 2013 - Taylor & Francis
Introduction: Autophagy is a conserved catabolic process crucial in maintaining cellular
homeostasis. On infection, oncolytic viruses (OVs) perturb the cellular autophagy machinery …