The carcinogen-induced rat mammary carcinoma model, developed a quarter of a century
ago by Dr. Charles Brenton Huggins, is today the standard laboratory animal model in the …

Among the multiple experimental animal models employed for analyzing the various aspects
of mammary carcinogenesis, the induction of mammary tumors in rats by chemical …

Breast cancer remains the major cancer among women in the United States in terms of
noncutaneous cancer incidence and the second leading cause of cancer deaths (1). Among …

In order to determine whether human breast epithelial cells undergo malignant
transformation when treated with chemical carcinogens in vitro, and how host factors, such …

Breast cancer, the most frequent spontaneousmalignancy diagnosed in women in the
Western world, isa classical model of hormone dependent malignancy. Thereis substantial …

We have previously indicated that the ideal animal tumor model should mimic the human
disease. This means that the investigator should be able to ascertain the influence of host …

Studies performed in experimental animal models have demonstrated that mammary cancer
is a complex multistep process that can be induced either by chemicals, radiation, viruses, or …

Breast cancer, the most frequent spontaneous malignancy diagnosed in women in the
western world, is continuously increasing in incidence in industrialized nations. Although …

One of the most consistent results in the epidemiology of human breast cancer is the inverse
relationship of risk and early full-term parity. The goal of this study was to investigate the …

Experimentally induced models of breast carcinogenesis in the rat are widely used for
studying the biology of breast cancer and for developing and evaluating cancer prevention …