Background Infantile spasms constitute a severe form of epileptic encephalopathy. In the
International Collaborative Infantile Spasms Study (ICISS), we showed that combining …

Background Infantile spasms constitutes a severe infantile epilepsy syndrome that is difficult
to treat and has a high morbidity. Hormonal therapies or vigabatrin are the most commonly …

Background Infantile spasms is the name given to a difficult to treat, severe infantile epilepsy
with high morbidity. The United Kingdom Infantile Spasms Study (UKISS) showed that …

Background Infantile spasms is a severe infantile seizure disorder that is difficult to treat and
has a high morbidity. Absence of spasms on days 13 and 14 after randomisation is more …

Objective Evaluation of efficacy of vigabatrin as the first drug in infants with previously
untreated infantile spasms (IS) and reporting the long‐term outcome. Methods We analyzed …

Background Infantile spasms, which comprise a severe infantile seizure disorder, have a
high morbidity and are difficult to treat. Hormonal treatments (adrenocorticotropic hormone …

Purpose: The efficacy and tolerability of vigabatrin (VGB) as an add‐on therapy in the
treatment of infantile spasm (IS) prompted physicians to explore its use as the first drug in …

Summary Purpose: Prior to the United Kingdom Infantile Spasms Study (UKISS), our
practice was to initiate vigabatrin for infantile spasms. However, since then we tend to use …

Objective Infantile spasms (IS) represent a severe epileptic encephalopathy presenting in
the first 2 years of life. Recommended first‐line therapies (hormonal therapy or vigabatrin) …

A large randomized study was conducted in patients with newly diagnosed infantile spasms
to compare 2 doses of vigabatrin in achieving spasm cessation. High (100-148 mg/kg/d) and …