Mapping mendelian factors underlying quantitative traits using RFLP linkage maps.

ES Lander, D Botstein - Genetics, 1989 - academic.oup.com
The advent of complete genetic linkage maps consisting of codominant DNA markers
[typically restriction fragment length polymorphisms (RFLPs)] has stimulated interest in the …

Mapping and analysis of quantitative trait loci in experimental populations

RW Doerge - Nature Reviews Genetics, 2002 - nature.com
Simple statistical methods for the study of quantitative trait loci (QTL), such as analysis of
variance, have given way to methods that involve several markers and high-resolution …

[PDF][PDF] Mapping genes controlling quantitative traits using MAPMAKER/QTL version 1.1: a tutorial and reference manual

SE Lincoln, MJ Daly, ES Lander - Whitehead Institute for …, 1993 - cse.unsw.edu.au
Over the last half century, a number of methods have been developed to map genes
controlling quantitatively measured phenotypes segregating in experimental populations. In …

Multiple trait analysis of genetic mapping for quantitative trait loci.

C Jiang, ZB Zeng - Genetics, 1995 - academic.oup.com
We present in this paper models and statistical methods for performing multiple trait analysis
on mapping quantitative trait loci (QTL) based on the composite interval mapping method …

Molecular dissection of quantitative traits: progress and prospects.

AH Paterson - Genome Research, 1995 - genome.cshlp.org
QTL mapping is an increasingly useful approach to the study and manipulation of complex
traits important in agriculture, evolution, and medicine. The molecular dissection of …

Theoretical basis for separation of multiple linked gene effects in mapping quantitative trait loci.

ZB Zeng - Proceedings of the National Academy of …, 1993 - National Acad Sciences
It is now possible to use complete genetic linkage maps to locate major quantitative trait loci
(QTLs) on chromosome regions. The current methods of QTL mapping (eg, interval …

Locating human quantitative trait loci: guidelines for the selection of sibling pairs for genotyping

L Eaves, J Meyer - Behavior Genetics, 1994 - Springer
Simulation studies were conducted to assess the relative merits of different nonrandom
sampling strategies for the selection of sibling pairs for genotyping in the attempt to locate …

Fine mapping of quantitative trait loci using linkage disequilibria with closely linked marker loci

THE Meuwissen, ME Goddard - Genetics, 2000 - academic.oup.com
A multimarker linkage disequilibrium mapping method was developed for the fine mapping
of quantitative trait loci (QTL) using a dense marker map. The method compares the …

Interval mapping of quantitative trait loci employing correlated trait complexes.

AB Korol, YI Ronin, VM Kirzhner - Genetics, 1995 - academic.oup.com
An approach to increase the resolution power of interval mapping of quantitative trait (QT)
loci is proposed, based on analysis of correlated trait complexes. For a given set of QTs, the …

Mapping complex genetic traits in humans: new methods using a complete RFLP linkage map

ES Lander, D Botstein - Cold Spring Harbor Symposia on …, 1986 - symposium.cshlp.org
It has been clear since the rediscovery of Mendel that humans obey laws of heredity
identical with those of other organisms. The central features of Mendelism were observable …