To achieve maximum fitness, pathogens must balance growth with tissue damage,
coordinating metabolism and virulence factor expression. In the gram-positive bacterium …

Catabolite control protein A (CcpA) is a highly conserved, master regulator of carbon source
utilization in gram-positive bacteria, but the CcpA regulon remains ill-defined. In this study …

Although central to pathogenesis, the molecular mechanisms used by microbes to regulate
virulence factor production in specific environments during host–pathogen interaction are …

CcpA globally regulates transcription in response to carbohydrate availability in many gram-
positive bacteria, but its role in Streptococcus mutans remains enigmatic. Using the fructan …

Many Gram-positive pathogens link the expression of virulence genes to the presence of
carbon source substrates using overlapping pathways for global control of carbon catabolite …

Microbial pathogens balance growth against tissue damage to achieve maximum fitness.
Central carbon metabolism is connected to growth, but how it influences growth/damage …

Catabolite control protein A (CcpA) is a master regulator of carbon source utilization and
contributes to the virulence of numerous medically important Gram‐positive bacteria. Most …

Carbon catabolite repression (CCR) allows bacteria to alter metabolism in response to the
availability of specific sugar sources, and increasing evidence suggests that CCR is …

We characterized the role of catabolite control protein A (ccpA) in the physiology and
virulence of Streptococcus pneumoniae. S. pneumoniae has a large percentage of its …

The Streptococcus mutans Cid/Lrg system represents an ideal model for studying this
organism's ability to withstand various stressors encountered in the oral cavity. The lrg and …