The regenerative process in the pancreas is of particular interest because diabetes results
from an inadequate number of insulin-producing beta cells and pancreatic cancer may arise …

The regenerative process in the pancreas is of particular interest, since diabetes, whether
Type 1 or Type 2, results from an inadequate amount of insulin-producing β-cells. Islet …

We examined the spectrum of intermediate cell types in the regenerating pancreas as duct
epithelial cells progressed through their differentiation pathway to become mature endocrine …

It has been suggested that pancreatic acinar cells can serve as progenitors for pancreatic
islets, a concept with substantial implications for therapeutic efforts to increase insulin …

Prospective isolation and characterization of progenitor cells is a paradigmatic strategy for
studies of organ development. However, extraction of viable cells, fractionation of lineages …

Aims/hypothesis The neogenesis of islets from cultured human adult pancreatic tissue has
been reported. The islet progenitors have been thought to be ductal cells. Since previous …

The elaboration of the pancreas from epithelial buds to the intricate organ requires complex
patterning information that controls fundamental cellular processes such as differentiation …

Pancreas homeostasis is based on replication of differentiated cells in order to maintain
proper organ size and function under changing physiological demand. Recent studies …

Diabetes is associated with a paucity of insulin-producing β-cells. With the goal of finding
therapeutic routes to treat diabetes, we aim to find molecular and cellular mechanisms …

With the increasing success of islet transplantation, β‐cell replacement therapy has had
renewed interest. To make such a therapy available to more than a few of the thousands of …