The transport of chloride and bicarbonate across epithelia controls the pH and volume of the
intracellular and luminal fluids, as well as the systemic pH and vascular volume. The anion …

Bicarbonate facilitates mucin unpacking and bacterial killing; however, its transport
mechanisms in the airways are not well understood. cAMP stimulates anion efflux through …

In most HCO 3−-secreting epithelial tissues, SLC26 Cl−/HCO 3− transporters work in concert
with the cystic fibrosis transmembrane conductance regulator (CFTR) to regulate the …

Bicarbonate facilitates mucin unpacking and bacterial killing; however, its transport
mechanisms in the airways are not well understood. cAMP stimulates anion efflux through …

Pendrin, first identified in 1997, belongs to a superfamily of anion transporters localized in
the thyroid gland, inner ear and kidney. Immunohistochemical studies have shown that …

Cystic Fibrosis (CF), an inherited multi‐system disease, is caused by mutations in the Cystic
Fibrosis Transmembrane Conductance Regulator (CFTR) that disrupt its ability to secrete …

Abstract Pendrin (SLC26A4) is a Cl−/anion exchanger expressed in the epithelium of
inflamed airways where it is thought to facilitate Cl− absorption and HCO 3− secretion …

The expression and function of the anion exchanger pendrin (SLC26A4) was thought to be
limited mainly to the inner ear, kidney and thyroid. Recent data indicates that pendrin is also …

Abstract Background/Aims: Pendrin is a Cl-/I-/HCO3-exchanger playing a fundamental role
in controlling blood pressure and airway function, therefore representing an attractive target …

Background: Human pendrin (SLC26A4, PDS) is an integral membrane protein acting as an
electroneutral anion exchanger. Loss of function mutations in pendrin protein cause …