Caenorhabditis elegans as a Model Organism to Evaluate the Antioxidant Effects of Phytochemicals

B Ayuda-Durán, S González-Manzano… - Molecules, 2020 - mdpi.com
The nematode Caenorhabditis elegans was introduced as a model organism in biological
research by Sydney Brenner in the 1970s. Since then, it has been increasingly used for …

Effects of Vegetal Extracts and Metabolites against Oxidative Stress and Associated Diseases: Studies in Caenorhabditis elegans

EY Hernández-Cruz, D Eugenio-Pérez… - ACS …, 2023 - ACS Publications
Oxidative stress is a natural physiological process where the levels of oxidants, such as
reactive oxygen species (ROS) and nitrogen (RNS), exceed the strategy of antioxidant …

Oxidation and Antioxidation of Natural Products in the Model Organism Caenorhabditis elegans

A Zhu, F Zheng, W Zhang, L Li, Y Li, H Hu, Y Wu… - Antioxidants, 2022 - mdpi.com
Natural products are small molecules naturally produced by multiple sources such as plants,
animals, fungi, bacteria and archaea. They exert both beneficial and detrimental effects by …

Increase of stress resistance and lifespan of Caenorhabditis elegans by quercetin

A Kampkötter, C Timpel, RF Zurawski, S Ruhl… - … and Physiology Part B …, 2008 - Elsevier
The health beneficial effects of a diet rich in fruits and vegetables are, at least in part,
attributed to polyphenols that are present in many herbal edibles. Although many in vitro …

[HTML][HTML] The redox system in C. elegans, a phylogenetic approach

AD Johnston, PR Ebert - Journal of toxicology, 2012 - ncbi.nlm.nih.gov
Oxidative stress is a toxic state caused by an imbalance between the production and
elimination of reactive oxygen species (ROS). ROS cause oxidative damage to cellular …

Adaptation to oxidative stress in young, but not in mature or old, Caenorhabditis elegans

D Darr, I Fridovich - Free Radical Biology and Medicine, 1995 - Elsevier
The effect of aging on the ability of Caenorhabditis elegans to adapt to oxidative stress was
examined. Oxidative stress was applied with the quinone plumbagin or with hyperoxia, both …

Reactive Oxygen Species and Aging in Caenorhabditis elegans: Causal or Casual Relationship?

JM Van Raamsdonk, S Hekimi - Antioxidants & redox signaling, 2010 - liebertpub.com
The free radical theory of aging proposes a causal relationship between reactive oxygen
species (ROS) and aging. While it is clear that oxidative damage increases with age, its role …

Bioactive components of the edible strain of red alga, Chondrus crispus, enhance oxidative stress tolerance in Caenorhabditis elegans

JS Sangha, D Fan, AH Banskota, R Stefanova… - Journal of Functional …, 2013 - Elsevier
Seaweeds are rich sources of bioactive compounds with potential health benefits. Anti-
stress effects of the cultivated red alga, Chondrus crispus, were investigated in the …

Effects of O-methylated metabolites of quercetin on oxidative stress, thermotolerance, lifespan and bioavailability on Caenorhabditis elegans

F Surco-Laos, J Cabello, E Gomez-Orte… - Food & function, 2011 - pubs.rsc.org
Quercetin is a major flavonoid in the human diet and the most commonly used in studies of
biological activity. Most of the knowledge about its biological effects has originated from in …

Exploring Target Genes Involved in the Effect of Quercetin on the Response to Oxidative Stress in Caenorhabditis elegans

B Ayuda-Durán, S González-Manzano… - Antioxidants, 2019 - mdpi.com
Quercetin is one the most abundant flavonoids in the human diet. Although it is well known
that quercetin exhibits a range of biological activities, the mechanisms behind these …