Intracellular reaction rates depend on concentrations and hence their levels are often
regulated. However classical models of stochastic gene expression lack a cell size …

Intracellular reaction rates depend on concentrations and hence their levels are often
regulated. However classical models of stochastic gene expression lack a cell size …

The cell division rate, size and gene expression programmes change in response to
external conditions. These global changes impact on average concentrations of biomolecule …

The standard model describing the fluctuations of mRNA numbers in single cells is the
telegraph model which includes synthesis and degradation of mRNA, and switching of the …

Highlights•Cellular growth, gene expression, and cell size are coordinated globally.•Cellular
growth is connected to protein numbers, noise, and gene networks dynamics.•Global …

Recently, there has been an increasing need for tools to simulate cell size regulation due to
important applications in cell proliferation and gene expression. However, implementing the …

Cell growth and gene expression, two essential elements of all living systems, have long
been the focus of biophysical interrogation. Advances in experimental single-cell methods …

Transcription is regulated by a multitude of factors that concertedly induce genes to switch
between activity states. Eukaryotic transcription involves a multitude of complexes that …

Gene expression is a complex stochastic process composed of numerous enzymatic
reactions with rates coupled to hidden cell-state variables. Despite advances in single-cell …

The stochasticity of gene expression is manifested in the fluctuations of messenger
ribonucleic acid and protein copy numbers within a cell lineage over time. While data of this …