[HTML][HTML] Assessment of costimulation and coinhibition in a triple parameter T cell reporter line: Simultaneous measurement of NF-κB, NFAT and AP-1
S Jutz, J Leitner, K Schmetterer, I Doel-Perez… - Journal of …, 2016 - Elsevier
Engagement of the T cell receptor complex reprograms T cells for proliferation, cytokine
production and differentiation towards effector cells. This process depends on activating …
production and differentiation towards effector cells. This process depends on activating …
[HTML][HTML] NFAT and NF-κB dynamically co-regulate TCR and CAR signaling responses in human T cells
While it has been established that the responses of T cells to antigens are combinatorially
regulated by multiple signaling pathways, it remains elusive what mechanisms cells utilize to …
regulated by multiple signaling pathways, it remains elusive what mechanisms cells utilize to …
It's all Rel-ative: NF-κB and CD28 costimulation of T-cell activation
Costimulatory signals complement or modify the signals provided to a lymphocyte through
antigen receptors. For productive T-cell activation, the CD28 molecule is apparently the most …
antigen receptors. For productive T-cell activation, the CD28 molecule is apparently the most …
NF-κB activation induced by T cell receptor/CD28 costimulation is mediated by protein kinase C-θ
N Coudronniere, M Villalba… - Proceedings of the …, 2000 - National Acad Sciences
Protein kinase C-θ (PKCθ) is a Ca2+-independent member of the PKC family that is
selectively expressed in skeletal muscle and T lymphocytes and plays an important role in T …
selectively expressed in skeletal muscle and T lymphocytes and plays an important role in T …
T helper cell-specific regulation of inducible costimulator expression via distinct mechanisms mediated by T-bet and GATA-3
Inducible costimulator (ICOS) expression is critical for T cell-mediated immunity. We showed
previously that T cell receptor and CD28 coengagement up-regulate ICOS expression in …
previously that T cell receptor and CD28 coengagement up-regulate ICOS expression in …
Controlling NF-κB activation in T cells by costimulatory receptors
ML Schmitz, D Krappmann - Cell Death & Differentiation, 2006 - nature.com
Full and productive activation of T lymphocytes relies on the simultaneous delivery of T cell
receptor (TCR)-and coreceptor-derived signals. In naïve T cells engagement of the TCR …
receptor (TCR)-and coreceptor-derived signals. In naïve T cells engagement of the TCR …
T‐cell tolerance or function is determined by combinatorial costimulatory signals
R Nurieva, S Thomas, T Nguyen… - The EMBO …, 2006 - embopress.org
Activated in immune responses, T lymphocytes differentiate into effector cells with potent
immune function. CD28 is the most prominent costimulatory receptor for T‐cell activation …
immune function. CD28 is the most prominent costimulatory receptor for T‐cell activation …
[HTML][HTML] TCR and CD28 activate the transcription factor NF-κB in T-cells via distinct adaptor signaling complexes
The transcription factor NF-κB is needed for the induction of inflammatory responses in T-
cells. Whether its activation by the antigen-receptor and CD28 is mediated by the same or …
cells. Whether its activation by the antigen-receptor and CD28 is mediated by the same or …
Regulation of NF-κB induction by TCR/CD28
NF-κB family transcription factors are a common downstream target for inducible
transcription mediated by many different cell-surface receptors, especially those receptors …
transcription mediated by many different cell-surface receptors, especially those receptors …
B7h, a novel costimulatory homolog of B7. 1 and B7. 2, is induced by TNFα
MM Swallow, JJ Wallin, CS William - Immunity, 1999 - cell.com
In a screen to identify genes induced by NF-κB/Rel transcription factors, we cloned a novel
gene, b7h, that is a close homolog of B7 costimulatory ligands expressed on antigen …
gene, b7h, that is a close homolog of B7 costimulatory ligands expressed on antigen …