Oxidative stress is an early hallmark in neurodegenerative disorders such as Alzheimer's
and Parkinson's diseases. However, the critical biochemical effector mechanisms of …

Oxidative stress is thought to be one of the main mediators of neuronal damage in human
neurodegenerative disease. Still, the dissection of causal relationships has turned out to be …

Publisher Summary Aging and age-related neurological disorders, especially Alzheimer's
disease (AD) and stroke, affect millions of people worldwide. Free radical-associated protein …

Lipid peroxidation is a biochemically adverse phenomenon with key involvement in many
different diseases including premature infant blindness, nonalcoholic steatohepatitis, or …

Numerous studies have shown that neuronal lipids are highly susceptible to oxidative stress
including in those brain areas directly involved in the neurodegenerative process of …

Oxyradicals attack double bonds of unsaturated fatty acids in cell membranes in a process
called membrane lipid peroxidation (MLP). This process occurs in many different acute and …

Lipid peroxidation is a complex process involving the interaction of oxygen-derived free
radicals with polyunsaturated fatty acids, resulting in a variety of highly reactive electrophilic …

Definitive evidence of oxygen radical-mediated lipid peroxidation as a cause of tissue injury
in the setting of brain ischemia has proven elusive. We review the experimental data from …

Young, adult, and old rats were used to study the effect of age on the integrity and
functioning of brain synaptosomes. An evaluation was made of the differences in lipid …

Lipid peroxidation involves a cascade of reactions in which production of free radicals
occurs selectively in the lipid components of cellular membranes. Polyunsaturated fatty …