A molecular mechanotransduction pathway regulates collective migration of epithelial cells
Collective movement of epithelial cells drives essential multicellular organization during
various fundamental physiological processes encompassing embryonic morphogenesis …
various fundamental physiological processes encompassing embryonic morphogenesis …
Mechanoreciprocity in cell migration
Cell migration is an adaptive process that depends on and responds to physical and
molecular triggers. Moving cells sense and respond to tissue mechanics and induce …
molecular triggers. Moving cells sense and respond to tissue mechanics and induce …
Collective cell guidance by cooperative intercellular forces
Cells comprising a tissue migrate as part of a collective. How collective processes are
coordinated over large multi-cellular assemblies has remained unclear, however, because …
coordinated over large multi-cellular assemblies has remained unclear, however, because …
Mechanobiology of collective cell behaviours
The way in which cells coordinate their behaviours during various biological processes,
including morphogenesis, cancer progression and tissue remodelling, largely depends on …
including morphogenesis, cancer progression and tissue remodelling, largely depends on …
Substrate area confinement is a key determinant of cell velocity in collective migration
Collective cell migration is fundamental throughout development, during wound healing and
in many diseases. Although much effort has focused on cell–cell junctions, a role for …
in many diseases. Although much effort has focused on cell–cell junctions, a role for …
Local and tissue-scale forces drive oriented junction growth during tissue extension
Convergence–extension is a widespread morphogenetic process driven by polarized cell
intercalation. In the Drosophila germ band, epithelial intercalation comprises loss of …
intercalation. In the Drosophila germ band, epithelial intercalation comprises loss of …
Interplay of RhoA and mechanical forces in collective cell migration driven by leader cells
The leading front of a collectively migrating epithelium often destabilizes into multicellular
migration fingers where a cell initially similar to the others becomes a leader cell while its …
migration fingers where a cell initially similar to the others becomes a leader cell while its …
The role of single-cell mechanical behaviour and polarity in driving collective cell migration
The directed migration of cell collectives is essential in various physiological processes,
such as epiboly, intestinal epithelial turnover, and convergent extension during …
such as epiboly, intestinal epithelial turnover, and convergent extension during …
Emerging modes of collective cell migration induced by geometrical constraints
SRK Vedula, MC Leong, TL Lai… - Proceedings of the …, 2012 - National Acad Sciences
The role of geometrical confinement on collective cell migration has been recognized but
has not been elucidated yet. Here, we show that the geometrical properties of the …
has not been elucidated yet. Here, we show that the geometrical properties of the …
Cellular locomotion using environmental topography
Eukaryotic cells migrate by coupling the intracellular force of the actin cytoskeleton to the
environment. While force coupling is usually mediated by transmembrane adhesion …
environment. While force coupling is usually mediated by transmembrane adhesion …
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