A molecular mechanotransduction pathway regulates collective migration of epithelial cells

T Das, K Safferling, S Rausch, N Grabe, H Boehm… - Nature cell …, 2015 - nature.com
Collective movement of epithelial cells drives essential multicellular organization during
various fundamental physiological processes encompassing embryonic morphogenesis …

Mechanoreciprocity in cell migration

S Van Helvert, C Storm, P Friedl - Nature cell biology, 2018 - nature.com
Cell migration is an adaptive process that depends on and responds to physical and
molecular triggers. Moving cells sense and respond to tissue mechanics and induce …

Collective cell guidance by cooperative intercellular forces

DT Tambe, C Corey Hardin, TE Angelini… - Nature materials, 2011 - nature.com
Cells comprising a tissue migrate as part of a collective. How collective processes are
coordinated over large multi-cellular assemblies has remained unclear, however, because …

Mechanobiology of collective cell behaviours

B Ladoux, RM Mège - Nature reviews Molecular cell biology, 2017 - nature.com
The way in which cells coordinate their behaviours during various biological processes,
including morphogenesis, cancer progression and tissue remodelling, largely depends on …

Substrate area confinement is a key determinant of cell velocity in collective migration

D Mohammed, G Charras, E Vercruysse, M Versaevel… - Nature Physics, 2019 - nature.com
Collective cell migration is fundamental throughout development, during wound healing and
in many diseases. Although much effort has focused on cell–cell junctions, a role for …

Local and tissue-scale forces drive oriented junction growth during tissue extension

C Collinet, M Rauzi, PF Lenne, T Lecuit - Nature cell biology, 2015 - nature.com
Convergence–extension is a widespread morphogenetic process driven by polarized cell
intercalation. In the Drosophila germ band, epithelial intercalation comprises loss of …

Interplay of RhoA and mechanical forces in collective cell migration driven by leader cells

M Reffay, MC Parrini, O Cochet-Escartin, B Ladoux… - Nature cell …, 2014 - nature.com
The leading front of a collectively migrating epithelium often destabilizes into multicellular
migration fingers where a cell initially similar to the others becomes a leader cell while its …

The role of single-cell mechanical behaviour and polarity in driving collective cell migration

S Jain, VML Cachoux, GHNS Narayana, S de Beco… - Nature physics, 2020 - nature.com
The directed migration of cell collectives is essential in various physiological processes,
such as epiboly, intestinal epithelial turnover, and convergent extension during …

Emerging modes of collective cell migration induced by geometrical constraints

SRK Vedula, MC Leong, TL Lai… - Proceedings of the …, 2012 - National Acad Sciences
The role of geometrical confinement on collective cell migration has been recognized but
has not been elucidated yet. Here, we show that the geometrical properties of the …

Cellular locomotion using environmental topography

A Reversat, F Gaertner, J Merrin, J Stopp, S Tasciyan… - Nature, 2020 - nature.com
Eukaryotic cells migrate by coupling the intracellular force of the actin cytoskeleton to the
environment. While force coupling is usually mediated by transmembrane adhesion …