Our previous studies demonstrated that oral administration of madecassoside could
markedly attenuate collagen-induced arthritis in rats, a rodent model of rheumatoid arthritis …

Madecassoside is the highest amount of triterpene constituent in Centella asiatica herbs, a
frequently prescribed crude drug in southeastern Asian and China for wound healing and …

Objective To explore the changes of intestinal mucosal immunity in collagen-induced
arthritis rats and the impact of madecassoside on these changes. Methods Collagen …

Madecassoside, a triterpenoid saponin present in Centella asiatica herbs with extremely low
bioavailability, possesses excellent anti-rheumatoid arthritis property after oral …

Madecassoside (MA), a triterpenoid product isolated from Centella asiatica, has been
described to exhibit antioxidant and anti-inflammatory activities. The present study was …

To develop a simple and highly sensitive high performance liquid chromatography with
electrospray ionization mass spectrometric (LC-ESI-MS) method for the simultaneous …

As a joint disease, osteoarthritis (OA) is caused by the breakdown of subchondral bone and
cartilage damage. Inflammatory factors, such as interleukin‐(IL‐) 1β, mediate the …

Fibroblast-like synoviocytes (FLS) play a pivotal role in Rheumatoid arthritis (RA)
pathogenesis through aggressive migration and invasion. Madecassoside (Madec), a …

Abstract Ethnopharmacological relevance Seeds of Caesalpinia minax Hance called 'Ku-Shi-
Lian'(KSL) in China have been used as Zhuang or Dai folk medicines for treatment of …

Previously, we reported that oral administration of madecassoside, the main active triterpene
in Centella asiatica L., exerted anti-arthritis effect by inducing the generation of regulatory T …