Genome-wide association studies (GWASs) have become the focus of the statistical analysis
of complex traits in humans, successfully shedding light on several aspects of genetic …

Interactions among loci or between genes and environmental factors make a substantial
contribution to variation in complex traits such as disease susceptibility. Nonetheless, many …

The widespread availability of high-throughput genotyping technology has opened the door
to the era of personal genetics, which brings to consumers the promise of using genetic …

The search for the missing heritability in genome‐wide association studies (GWAS) has
become an important focus for the human genetics community. One suspected location of …

Non-additive interaction between genetic variants, or epistasis, is a possible explanation for
the gap between heritability of complex traits and the variation explained by identified …

Studies in model organisms suggest that epistasis may play an important role in the etiology
of complex diseases and traits in humans. With the era of large-scale genome-wide …

Over the last few years, main effect genetic association analysis has proven to be a
successful tool to unravel genetic risk components to a variety of complex diseases. In the …

There is increasing awareness that epistasis or gene-gene interaction plays a role in
susceptibility to common human diseases. In this paper, we formulate a working hypothesis …

Background The variance explained by genetic variants as identified in (genome-wide)
genetic association studies is typically small compared to family-based heritability estimates …

During the past decade, findings of genome-wide association studies (GWAS) improved our
knowledge and understanding of disease genetics. To date, thousands of SNPs have been …