The reaction takes place at a specialized metal center that dramatically increases the acidity
of H2 and leads to a heterolytic splitting of the molecule which is strongly accelerated by the …

Providing an abundant, clean, and secure renewable energy source is one of the key
technological challenges facing mankind. Resurgence in the chemistry and biochemistry of …

The activation of molecular hydrogen is of interest both from a chemical and biological
viewpoint. The covalent bond of H2 is strong (436 kJ mol− 1). Its cleavage is catalyzed by …

Many microorganisms, such as methanogenic, acetogenic, nitrogen-fixing, photosynthetic,
or sulfate-reducing bacteria, metabolize hydrogen.[1, 2a] Hydrogen activation is mediated by …

If the atmosphere of the early Earth was hydrogen-rich, 1 it is reasonable to think that
hydrogenases, the enzymes enabling cells to use molecular hydrogen, were probably …

Hydrogen is being considered as a versatile alternative fuel with the ever increasing energy
demand and oil prices. Hydrogenases (H2ases) found in bacteria, archaea and eukaryotes …

Hydrogenases are enzymes capable of catalyzing the oxidation of molecular hydrogen or its
production from protons and electrons according to the reversible reaction: H2⇌ 2H++ 2e …

The utilization of hydrogen by micro-organisms as a source of reducing power or of protons
as final electron acceptors is mediated by metalloenzymes called hydrogenases. The need …

Hydrogenase enzymes in nature use hydrogen as a fuel, but the heterolytic cleavage of H
H bonds cannot be readily observed in enzymes. Here we show that an iron complex with …

This article sets out to review the chemistry relating to the synthesis of structural and
functional analogues of the three classes of hydrogenases. This chemistry has grown …