[HTML][HTML] Integrative transcriptome and chromatin landscape analysis reveals distinct epigenetic regulations in human memory B cells
Memory B cells (MBCs) are long-lived and produce high-affinity, generally, class-switched
antibodies. Here, we use a multiparameter approach involving CD27 to segregate naïve B …
antibodies. Here, we use a multiparameter approach involving CD27 to segregate naïve B …
[HTML][HTML] CD80 and PD-L2 define functionally distinct memory B cell subsets that are independent of antibody isotype
GV Zuccarino-Catania, S Sadanand, FJ Weisel… - Nature …, 2014 - nature.com
Memory B cells (MBCs) are long-lived sources of rapid, isotype-switched secondary
antibody-forming cell (AFC) responses. Whether MBCs homogeneously retain the ability to …
antibody-forming cell (AFC) responses. Whether MBCs homogeneously retain the ability to …
Memory B cell subsets have divergent developmental origins that are coupled to distinct imprinted epigenetic states
Memory B cells (MBCs) are phenotypically and functionally diverse, but their developmental
origins remain undefined. Murine MBCs can be divided into subsets by expression of CD80 …
origins remain undefined. Murine MBCs can be divided into subsets by expression of CD80 …
[HTML][HTML] The interplay between CD27dull and CD27bright B cells ensures the flexibility, stability, and resilience of human B cell memory
Memory B cells (MBCs) epitomize the adaptation of the immune system to the environment.
We identify two MBC subsets in peripheral blood, CD27 dull and CD27 bright MBCs, whose …
We identify two MBC subsets in peripheral blood, CD27 dull and CD27 bright MBCs, whose …
Complexity of the human memory B-cell compartment is determined by the versatility of clonal diversification in germinal centers
B Budeus, S Schweigle de Reynoso… - Proceedings of the …, 2015 - National Acad Sciences
Our knowledge about the clonal composition and intraclonal diversity of the human memory
B-cell compartment and the relationship between memory B-cell subsets is still limited …
B-cell compartment and the relationship between memory B-cell subsets is still limited …
[HTML][HTML] Human IgM–expressing memory B cells
A hallmark of T cell dependent (TD) humoral immune responses is the generation of long–
lived memory B cells. The generation of these cells occurs primarily in the germinal center …
lived memory B cells. The generation of these cells occurs primarily in the germinal center …
Class-switched memory B cells remodel BCRs within secondary germinal centers
LJ McHeyzer-Williams, PJ Milpied, SL Okitsu… - Nature …, 2015 - nature.com
Effective vaccines induce high-affinity memory B cells and durable antibody responses
through accelerated mechanisms of natural selection. Secondary changes in antibody …
through accelerated mechanisms of natural selection. Secondary changes in antibody …
[HTML][HTML] Memory B cell diversity: insights for optimized vaccine design
The overarching logos of mammalian memory B cells (MBCs) is to cache the potential for
enhanced antibody production upon secondary exposure to cognate antigenic …
enhanced antibody production upon secondary exposure to cognate antigenic …
Human IgG2‐and IgG4‐expressing memory B cells display enhanced molecular and phenotypic signs of maturity and accumulate with age
BG De Jong, H IJspeert, L Marques… - Immunology and cell …, 2017 - Wiley Online Library
The mechanisms involved in sequential immunoglobulin G (IgG) class switching are still
largely unknown. Sequential IG class switching is linked to higher levels of somatic …
largely unknown. Sequential IG class switching is linked to higher levels of somatic …
Memory B cells of mice and humans
F Weisel, M Shlomchik - Annual review of immunology, 2017 - annualreviews.org
We comprehensively review memory B cells (MBCs), covering the definition of MBCs and
their identities and subsets, how MBCs are generated, where they are localized, how they …
their identities and subsets, how MBCs are generated, where they are localized, how they …