Since Bateson's discovery that genes can suppress the phenotypic effects of other genes,
gene interactions—called epistasis—have been the topic of a vast research effort. Systems …

The role of epistasis in the genetic architecture of quantitative traits is controversial, despite
the biological plausibility that nonlinear molecular interactions underpin the genotype …

Over the last two decades, research into epistasis has seen explosive growth and has
moved the focus of research in evolutionary genetics from a traditional additive approach …

Patterns of epistasis and shapes of fitness landscapes are of wide interest because of their
bearings on a number of evolutionary theories. The common phenomena of slowing fitness …

Organisms are built from thousands of genes that interact in complex ways. Still, the
mathematical theory of evolution is dominated by a gene-by-gene perspective in which …

Epistasis occurs when the effect of a mutation depends on its carrier's genetic background.
Despite increasing evidence that epistasis for fitness is common, its role during evolution is …

Epistasis for fitness means that the selective effect of a mutation is conditional on the genetic
background in which it appears. Although epistasis is widely observed in nature, our …

Whether systematic genetic interactions (epistasis) occur at the genomic scale remains a
challenging topic in evolutionary biology. Epistasis should make a significant contribution to …

The structure, function, and evolution of proteins depend on physical and genetic
interactions among amino acids. Recent studies have used new strategies to explore the …

Over the last decade, the genomic revolution has offered the possibility to generate
tremendous amounts of data that contain valuable information on the genetic basis of …