[HTML][HTML] Cellular mitophagy: mechanism, roles in diseases and small molecule pharmacological regulation

Y Lu, Z Li, S Zhang, T Zhang, Y Liu, L Zhang - Theranostics, 2023 - ncbi.nlm.nih.gov
Cellular mitophagy means that cells selectively wrap and degrade damaged mitochondria
through an autophagy mechanism, thus maintaining mitochondria and intracellular …

[HTML][HTML] Emerging role of mitophagy in human diseases and physiology

JH Um, J Yun - BMB reports, 2017 - ncbi.nlm.nih.gov
Mitophagy is a process of selective removal of damaged or unnecessary mitochondria using
autophagic machinery. Mitophagy plays an essential role in maintaining mitochondrial …

Outstanding questions in mitophagy: what we do and do not know

L Montava-Garriga, IG Ganley - Journal of molecular biology, 2020 - Elsevier
The elimination of mitochondria via autophagy, termed mitophagy, is an evolutionarily
conserved mechanism for mitochondrial quality control and homeostasis. Mitophagy …

The mitophagy pathway and its implications in human diseases

S Wang, H Long, L Hou, B Feng, Z Ma, Y Wu… - Signal transduction and …, 2023 - nature.com
Mitochondria are dynamic organelles with multiple functions. They participate in necrotic cell
death and programmed apoptotic, and are crucial for cell metabolism and survival …

Molecular mechanisms of mitophagy and its roles in neurodegenerative diseases

X Li, L Huang, J Lan, X Feng, P Li, L Wu… - Pharmacological …, 2021 - Elsevier
Neurodegenerative diseases are the most common diseases of the nervous system in
elderly people, which are currently incurable and cause great burden to families and …

Mitophagy regulates neurodegenerative diseases

X Cen, M Zhang, M Zhou, L Ye, H Xia - Cells, 2021 - mdpi.com
Mitochondria play an essential role in supplying energy for the health and survival of
neurons. Mitophagy is a metabolic process that removes dysfunctional or redundant …

Mitophagy mechanisms and role in human diseases

M Redmann, M Dodson, M Boyer-Guittaut… - The international journal …, 2014 - Elsevier
Mitophagy is a process of mitochondrial turnover through lysosomal mediated autophagy
activities. This review will highlight recent studies that have identified mediators of …

Mechanisms of mitophagy in cellular homeostasis, physiology and pathology

K Palikaras, E Lionaki, N Tavernarakis - Nature cell biology, 2018 - nature.com
Mitophagy is an evolutionarily conserved cellular process to remove dysfunctional or
superfluous mitochondria, thus fine-tuning mitochondrial number and preserving energy …

Neuronal mitophagy: friend or foe?

C Doxaki, K Palikaras - Frontiers in cell and developmental biology, 2021 - frontiersin.org
Maintenance of neuronal homeostasis is a challenging task, due to unique cellular
organization and bioenergetic demands of post-mitotic neurons. It is increasingly …

Mitophagy in human diseases

L Doblado, C Lueck, C Rey, AK Samhan-Arias… - International journal of …, 2021 - mdpi.com
Mitophagy is a selective autophagic process, essential for cellular homeostasis, that
eliminates dysfunctional mitochondria. Activated by inner membrane depolarization, it plays …