[HTML][HTML] Entamoeba histolytica exacerbates epithelial tight junction permeability and proinflammatory responses in Muc2−/− mice
V Kissoon-Singh, F Moreau, E Trusevych… - The American journal of …, 2013 - Elsevier
Human mucin-2 (MUC-2) is the first line of innate host defense in preventing pathogen-
induced epithelial injury. Entamoeba histolytica (Eh) colonizes the mucus layer by binding of …
induced epithelial injury. Entamoeba histolytica (Eh) colonizes the mucus layer by binding of …
[HTML][HTML] Immune Evasion Mechanisms of Entamoeba histolytica: Progression to Disease
S Begum, J Quach, K Chadee - Frontiers in microbiology, 2015 - frontiersin.org
Entamoeba histolytica (Eh) is a protozoan parasite that infects 10% of the world's population
and results in 100,000 deaths/year from amebic dysentery and/or liver abscess. In most …
and results in 100,000 deaths/year from amebic dysentery and/or liver abscess. In most …
Entamoeba histolytica-Induced Mucin Exocytosis Is Mediated by VAMP8 and Is Critical in Mucosal Innate Host Defense
S Cornick, F Moreau, HY Gaisano, K Chadee - MBio, 2017 - Am Soc Microbiol
Intestinal mucus secretion is critical in maintaining mucosal host defense against a myriad of
pathogens by preventing direct association with the epithelium. Entamoeba histolytica …
pathogens by preventing direct association with the epithelium. Entamoeba histolytica …
[HTML][HTML] Entamoeba histolytica Cysteine Proteinase 5 Evokes Mucin Exocytosis from Colonic Goblet Cells via αvβ3 Integrin
S Cornick, F Moreau, K Chadee - PLOS pathogens, 2016 - journals.plos.org
Critical to the pathogenesis of intestinal amebiasis, Entamoeba histolytica (Eh) induces
mucus hypersecretion and degrades the colonic mucus layer at the site of invasion. The …
mucus hypersecretion and degrades the colonic mucus layer at the site of invasion. The …
Entamoeba histolytica cysteine proteases cleave the MUC2 mucin in its C-terminal domain and dissolve the protective colonic mucus gel
ME Lidell, DM Moncada, K Chadee… - Proceedings of the …, 2006 - National Acad Sciences
In order for the protozoan parasite Entamoeba histolytica (Eh) to cause invasive intestinal
and extraintestinal infection, which leads to significant morbidity and mortality, it must disrupt …
and extraintestinal infection, which leads to significant morbidity and mortality, it must disrupt …
[HTML][HTML] Defining cooperative roles for colonic microbiota and Muc2 mucin in mediating innate host defense against Entamoeba histolytica
A Leon-Coria, M Kumar, F Moreau, K Chadee - PLoS pathogens, 2018 - journals.plos.org
Amebiasis is caused by the protozoan parasite Entamoeba histolytica (Eh), a potentially fatal
disease occurring mainly in developing countries. How Eh interacts with innate host factors …
disease occurring mainly in developing countries. How Eh interacts with innate host factors …
The delicate balance between Entamoeba histolytica, mucus and microbiota
A Leon-Coria, M Kumar, K Chadee - Gut microbes, 2020 - Taylor & Francis
Entamoeba histolytica (Eh) is a protozoan parasite of humans that colonizes the outer
colonic mucus layer. Under conditions not fully understood, Eh breaches innate host …
colonic mucus layer. Under conditions not fully understood, Eh breaches innate host …
[HTML][HTML] Prostaglandin E2 produced by Entamoeba histolytica signals via EP4 receptor and alters claudin-4 to increase ion permeability of tight junctions
M Lejeune, F Moreau, K Chadee - The American journal of pathology, 2011 - Elsevier
Entamoeba histolytica is a protozoan parasite that causes amebic dysentery characterized
by severe watery diarrhea. Unfortunately, the parasitic factors involved in the pathogenesis …
by severe watery diarrhea. Unfortunately, the parasitic factors involved in the pathogenesis …
Antisense inhibition of Entamoeba histolytica cysteine proteases inhibits colonic mucus degradation
D Moncada, K Keller, S Ankri, D Mirelman, K Chadee - Gastroenterology, 2006 - Elsevier
Background & Aims: The exact role Entamoeba histolytica cysteine proteases play in
overcoming the colonic mucus barrier, as a prerequisite to epithelial cell disruption, is not …
overcoming the colonic mucus barrier, as a prerequisite to epithelial cell disruption, is not …
[HTML][HTML] Gal-lectin-dependent contact activates the inflammasome by invasive Entamoeba histolytica
L Mortimer, F Moreau, S Cornick, K Chadee - Mucosal immunology, 2014 - Elsevier
Entamoeba histolytica (Eh) is an extracellular protozoan parasite of the human colon, which
occasionally breaches the intestinal barrier. Eradicating ameba that invades is essential for …
occasionally breaches the intestinal barrier. Eradicating ameba that invades is essential for …
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