Immunopathology of rheumatoid arthritis

JL Pablos, JD Canete - Current topics in medicinal chemistry, 2013 - ingentaconnect.com
Rheumatoid arthritis (RA) is one of the most common autoimmune diseases. Genetic and
epidemiologic studies point to a relevant role of adaptive T-cell response interactions with …

Rheumatoid arthritis: from basic findings and clinical manifestations to future therapies

P Hasler, C Gabay - Seminars in immunopathology, 2017 - Springer
It has been over 10 years since the topic of rheumatoid arthritis (RA) was considered in the
pages of Seminars in Immunopathology [1]. At the time, the focus was on the biologics …

Rheumatoid arthritis: pathogenic mechanisms and therapeutic targets

PC Taylor, M Feldmann - Drug Discovery Today: Disease Mechanisms, 2004 - Elsevier
Numerous novel therapies are in development for rheumatoid arthritis as a consequence of
tremendous progress in understanding pathogenic mechanisms and defining relevant …

Insights into the treatment of rheumatoid arthritis: a paradigm in medicine

JS Smolen - Journal of autoimmunity, 2020 - Elsevier
Insights into rheumatoid arthritis (RA) have slowly evolved over the last century, but with
breathtaking speed over the last 2 decades. While only aspirin and parenteral gold were …

[HTML][HTML] New druggable targets for rheumatoid arthritis based on insights from synovial biology

G Sandhu, BK Thelma - Frontiers in Immunology, 2022 - frontiersin.org
Rheumatoid arthritis (RA) is a multifactorial autoimmune disease characterized by chronic
inflammation and destruction of multiple small joints which may lead to systemic …

New therapeutic approaches for rheumatoid arthritis

Q Chen, W Wei - Assay and Drug Development Technologies, 2005 - liebertpub.com
Rheumatoid arthritis (RA) is a chronic polyarthritis leading to joint destruction and
remarkable disability. Current therapies have various degrees of efficacy, but toxicity …

Rheumatoid arthritis: regulation of synovial inflammation

SE Sweeney, GS Firestein - The international journal of biochemistry & cell …, 2004 - Elsevier
Rheumatoid arthritis (RA) is a systemic, inflammatory autoimmune disorder that presents as
a symmetric polyarthritis associated with swelling and pain in multiple joints, often initially …

[PDF][PDF] Immune mechanisms and novel targets in rheumatoid arthritis

S Venuturupalli - Immunology and Allergy Clinics, 2017 - 123library.org
Over the past several decades, immense progress has been made in the understanding of
the immune mechanisms and cytokine networks that contribute to the development and …

Biological targets in the treatment of rheumatoid arthritis: a comprehensive review of current and in-development biological disease modifying anti-rheumatic drugs

M Kukar, O Petryna, P Efthimiou - Biologics: Targets and Therapy, 2009 - Taylor & Francis
Enhanced understanding of the rheumatoid arthritis (RA) pathophysiology and the role of
cytokines has enabled the development of innovative biological agents in the last 10 years …

Rheumatoid arthritis: from autoimmunity to synovitis and joint destruction

MC Boissier, L Semerano, S Challal… - Journal of …, 2012 - Elsevier
Rheumatoid arthritis is an autoimmune disease characterized by the production of two
known antibodies–rheumatoid factor and anti-citrullinated peptide antibody (ACPA)–against …