Background Lithium, the prototypical mood stabilizer, and quetiapine, a second-generation
antipsychotic, are widely used acute and maintenance pharmacotherapies for bipolar …

Objective: To evaluate the efficacy and tolerability of quetiapine monotherapy versus
placebo for the treatment of mania associated with bipolar disorder. Method: In an …

Background: Bipolar disorder is among the 10 most disabling medical conditions worldwide.
While lithium has been used extensively for bipolar disorder since the 1970s, second …

Continuation treatment for bipolar disorder often consists of a mood stabilizer and a second-
generation antipsychotic. Quetiapine has been shown to be an effective treatment for acute …

Quetiapine has been proposed for depression in bipolar patients but a quantitative analysis
is lacking. In the present paper, we review and meta-analyze available data about the short …

The aim of this study was to evaluate the efficacy and tolerability of quetiapine combined
with lithium or divalproex in the treatment of bipolar mania. Patients were randomized to 6 …

Bipolar depression is more common, disabling, and difficult-to-treat than the manic and
hypomanic phases that define bipolar disorder. Unlike the treatment of so-called “unipolar” …

Background Classic and second-generation antipsychotic mood stabilizers are
recommended for treatment of bipolar disorder, yet there are no randomized comparative …

Objective: The aim of this study was to compare the efficacy and tolerability of quetiapine
and lithium monotherapy with that of placebo for a major depressive episode in bipolar …

Objective: Evaluate the efficacy and tolerability of quetiapine (QTP) combined with lithium
(Li) or divalproex (DVP) in the treatment of acute mania. Methods: Patients were randomized …