Therapeutic effects of an aspalathin-rich green rooibos extract, pioglitazone and atorvastatin combination therapy in diabetic db/db mice
O Patel, CJF Muller, E Joubert, B Rosenkranz, J Louw… - PloS one, 2021 - journals.plos.org
Oral therapeutics used to treat type 2 diabetes and cardiovascular disease often fail to
prevent the progression of disease and their comorbidities. Rooibos (Aspalathus linearis) …
prevent the progression of disease and their comorbidities. Rooibos (Aspalathus linearis) …
[HTML][HTML] Pharmacokinetic interaction of green rooibos extract with atorvastatin and metformin in rats
O Patel, CJF Muller, E Joubert, B Rosenkranz… - Frontiers in …, 2019 - frontiersin.org
An aspalathin-rich green rooibos extract (Afriplex GRT™) has demonstrated anti-diabetic
and hypolipidemic properties, while also moderately inhibiting CYP3A4 activity, suggesting …
and hypolipidemic properties, while also moderately inhibiting CYP3A4 activity, suggesting …
Antidiabetic effect of green rooibos (Aspalathus linearis) extract in cultured cells and type 2 diabetic model KK-Ay mice
R Kamakura, MJ Son, D de Beer, E Joubert, Y Miura… - Cytotechnology, 2015 - Springer
Previous studies have demonstrated antidiabetic effects for rooibos (Aspalathus linearis)
and aspalathin (ASP), one of its main polyphenols. Rooibos, an endemic plant of South …
and aspalathin (ASP), one of its main polyphenols. Rooibos, an endemic plant of South …
Green rooibos extract improves plasma lipid profile and oxidative status in diabetic non-human primates
P Orlando, N Chellan, CJF Muller, J Louw… - Free Radical Biology …, 2017 - Elsevier
Rooibos, a shrub-like leguminous bush endemic to South Africa, is traditionally used as a
herbal tea. Unfermented (green) rooibos presents with a much higher polyphenol content, in …
herbal tea. Unfermented (green) rooibos presents with a much higher polyphenol content, in …
Aspalathin-rich green rooibos extract lowers LDL-cholesterol and oxidative status in high-fat diet-induced diabetic vervet monkeys
P Orlando, N Chellan, J Louw, L Tiano, I Cirilli… - Molecules, 2019 - mdpi.com
Type 2 diabetic patients possess a two to four-fold-increased risk for cardiovascular
diseases (CVD). Hyperglycemia, oxidative stress associated with endothelial dysfunction …
diseases (CVD). Hyperglycemia, oxidative stress associated with endothelial dysfunction …
Xuezhikang contributes to greater triglyceride reduction than simvastatin in hypertriglyceridemia rats by up-regulating apolipoprotein A5 via the PPARα signaling …
S Zhao, R Li, W Dai, B Yu, L Chen, X Huang - PLoS One, 2017 - journals.plos.org
Xuezhikang (XZK), an extract of Chinese red yeast rice, is recommended as an optimal
choice for patients with coronary heart disease (CHD) with markedly elevated triglyceride …
choice for patients with coronary heart disease (CHD) with markedly elevated triglyceride …
Aspalathin, a C-glucosyldihydrochalcone from rooibos improves the hypoglycemic potential of metformin in type 2 diabetic (db/db) mice
PV Dludla, KB Gabuza, CJF Muller, E Joubert, J Louw… - 2018 - scholar.sun.ac.za
Metformin is the first line therapy of type 2 diabetics, but continued reduction of their life
expectancy warrants further investigation into alternative treatment strategies. This study …
expectancy warrants further investigation into alternative treatment strategies. This study …
A beneficial role of rooibos in diabetes mellitus: a systematic review and meta-analysis
M Sasaki, N Nishida, M Shimada - Molecules, 2018 - mdpi.com
In a rapid increase in cases of diabetes mellitus worldwide, there has been interested in the
use of plant-derived polyphenols as nutraceuticals to prevent the onset and progression of …
use of plant-derived polyphenols as nutraceuticals to prevent the onset and progression of …
Investigating the modulating effects of Afriplex GRT Extract on vascular function and antioxidant status in obese Wistar rat
Z Maqeda - 2018 - scholar.sun.ac.za
Introduction Obesity is associated with the development of metabolic syndrome, a
conglomerate of cardiometabolic risk factors, which synergistically result in cardiovascular …
conglomerate of cardiometabolic risk factors, which synergistically result in cardiovascular …
Red clover extract ameliorates dyslipidemia in streptozotocin‐induced diabetic C57BL/6 mice by activating hepatic PPARα
L Qiu, H Ye, L Chen, Y Hong, F Zhong… - Phytotherapy …, 2012 - Wiley Online Library
The effects of red clover extract and its bioactive components, biochanin A and
formononetin, on the blood glucose and lipid levels of streptozotocin (STZ) induced‐diabetic …
formononetin, on the blood glucose and lipid levels of streptozotocin (STZ) induced‐diabetic …
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