Fructose 2, 6-bisphosphate in cancer cell metabolism
R Bartrons, H Simon-Molas, A Rodríguez-García… - Frontiers in …, 2018 - frontiersin.org
For a long time, pioneers in the field of cancer cell metabolism, such as Otto Warburg, have
focused on the idea that tumor cells maintain high glycolytic rates even with adequate …
focused on the idea that tumor cells maintain high glycolytic rates even with adequate …
Balancing glycolytic flux: the role of 6-phosphofructo-2-kinase/fructose 2, 6-bisphosphatases in cancer metabolism
The increased glucose metabolism in cancer cells is required to fulfill their high energetic
and biosynthetic demands. Changes in the metabolic activity of cancer cells are caused by …
and biosynthetic demands. Changes in the metabolic activity of cancer cells are caused by …
[HTML][HTML] 6-Phosphofructo-2-kinase/fructose-2, 6-biphosphatase 3 and 4: A pair of valves for fine-tuning of glucose metabolism in human cancer
M Yi, Y Ban, Y Tan, W Xiong, G Li, B Xiang - Molecular metabolism, 2019 - Elsevier
Background Cancer cells favor the use of less efficient glycolysis rather than mitochondrial
oxidative phosphorylation to metabolize glucose, even in oxygen-rich conditions, a distinct …
oxidative phosphorylation to metabolize glucose, even in oxygen-rich conditions, a distinct …
[HTML][HTML] Fructose-2, 6-bisphosphate synthesis by 6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase 4 (PFKFB4) is required for the glycolytic response to hypoxia …
J Chesney, J Clark, AC Klarer, Y Imbert-Fernandez… - Oncotarget, 2014 - ncbi.nlm.nih.gov
Abstract Fructose-2, 6-bisphosphate (F2, 6BP) is a shunt product of glycolysis that
allosterically activates 6-phosphofructo-1-kinase (PFK-1) resulting in increased glucose …
allosterically activates 6-phosphofructo-1-kinase (PFK-1) resulting in increased glucose …
6-Phosphofructo-2-kinase (PFKFB3) promotes cell cycle progression and suppresses apoptosis via Cdk1-mediated phosphorylation of p27
The control of glucose metabolism and the cell cycle must be coordinated in order to
guarantee sufficient ATP and anabolic substrates at distinct phases of the cell cycle. The …
guarantee sufficient ATP and anabolic substrates at distinct phases of the cell cycle. The …
[HTML][HTML] The molecular basis of targeting PFKFB3 as a therapeutic strategy against cancer
L Lu, Y Chen, Y Zhu - Oncotarget, 2017 - ncbi.nlm.nih.gov
phosphofructo-2-kinase/fructose-2, 6-bisphosphatases (PFKFBs) are bifunctional enzymes
which regulate the transformation between fructose-2, 6-bisphosphate (F2, 6BP) and …
which regulate the transformation between fructose-2, 6-bisphosphate (F2, 6BP) and …
6-Phosphofructo-2-kinase/fructose-2, 6-biphosphatase 4 is essential for p53-null cancer cells
Abstract The bifunctional enzyme 6-phosphofructo-2-kinase/fructose-2, 6-biphosphatase-4
(PFKFB4) controls metabolic flux through allosteric regulation of glycolysis. Here we show …
(PFKFB4) controls metabolic flux through allosteric regulation of glycolysis. Here we show …
Small-molecule inhibition of 6-phosphofructo-2-kinase activity suppresses glycolytic flux and tumor growth
B Clem, S Telang, A Clem, A Yalcin, J Meier… - Molecular cancer …, 2008 - AACR
Phosphofructo-1-kinase, a rate-limiting enzyme of glycolysis, is activated in neoplastic cells
by fructose-2, 6-bisphosphate (Fru-2, 6-BP), a product of four 6-phosphofructo-2 …
by fructose-2, 6-bisphosphate (Fru-2, 6-BP), a product of four 6-phosphofructo-2 …
The potential utility of PFKFB3 as a therapeutic target
R Bartrons, A Rodríguez-García… - Expert opinion on …, 2018 - Taylor & Francis
Introduction: It has been known for over half a century that tumors exhibit an increased
demand for nutrients to fuel their rapid proliferation. Interest in targeting cancer metabolism …
demand for nutrients to fuel their rapid proliferation. Interest in targeting cancer metabolism …
Regulation of glucose metabolism by 6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatases in cancer
A Yalcin, S Telang, B Clem, J Chesney - Experimental and molecular …, 2009 - Elsevier
A high rate of glycolytic flux, even in the presence of oxygen, is a central metabolic hallmark
of neoplastic tumors. Cancer cells preferentially utilize glycolysis in order to satisfy their …
of neoplastic tumors. Cancer cells preferentially utilize glycolysis in order to satisfy their …