For a long time, pioneers in the field of cancer cell metabolism, such as Otto Warburg, have
focused on the idea that tumor cells maintain high glycolytic rates even with adequate …

The increased glucose metabolism in cancer cells is required to fulfill their high energetic
and biosynthetic demands. Changes in the metabolic activity of cancer cells are caused by …

Background Cancer cells favor the use of less efficient glycolysis rather than mitochondrial
oxidative phosphorylation to metabolize glucose, even in oxygen-rich conditions, a distinct …

Abstract Fructose-2, 6-bisphosphate (F2, 6BP) is a shunt product of glycolysis that
allosterically activates 6-phosphofructo-1-kinase (PFK-1) resulting in increased glucose …

The control of glucose metabolism and the cell cycle must be coordinated in order to
guarantee sufficient ATP and anabolic substrates at distinct phases of the cell cycle. The …

phosphofructo-2-kinase/fructose-2, 6-bisphosphatases (PFKFBs) are bifunctional enzymes
which regulate the transformation between fructose-2, 6-bisphosphate (F2, 6BP) and …

Abstract The bifunctional enzyme 6-phosphofructo-2-kinase/fructose-2, 6-biphosphatase-4
(PFKFB4) controls metabolic flux through allosteric regulation of glycolysis. Here we show …

Phosphofructo-1-kinase, a rate-limiting enzyme of glycolysis, is activated in neoplastic cells
by fructose-2, 6-bisphosphate (Fru-2, 6-BP), a product of four 6-phosphofructo-2 …

Introduction: It has been known for over half a century that tumors exhibit an increased
demand for nutrients to fuel their rapid proliferation. Interest in targeting cancer metabolism …

Tumor cells increase glucose metabolism through glycolysis and pentose phosphate
pathways to meet the bioenergetic and biosynthetic demands of rapid cell proliferation. The …