Understanding the molecular mechanisms of nociception has recently grown impressively.
Nociception is mediated by mechanical, chemical, or microbial stimuli that evoke unpleasant …

Nociceptors and immune cells both protect the host from potential threats to homeostasis.
There is growing evidence for bidirectional signalling between these two systems, and the …

Nociceptors have emerged as master regulators of immune responses in both homeostatic
and pathologic settings; however, their seemingly contradictory effects on the functions of …

Emerging research shows that nociceptor neurons could significantly affect the immune
response and inflammation. Thus, pain is not only a cardinal feature of inflammation but also …

Pain is a hallmark of tissue injury, inflammatory diseases, pathogen invasion and
neuropathy. It is mediated by nociceptor sensory neurons that innervate the skin, joints …

Nociceptors comprise a subpopulation of specialised sensory neurons capable of sensing
and responding to (potentially) harmful stimuli. This process, termed nociception and often …

Nociceptor sensory neurons protect organisms from danger by eliciting pain and driving
avoidance. Pain also accompanies many types of inflammation and injury. It is increasingly …

The immune system has evolved to protect the host from infectious agents, parasites, and
tumor growth, and to ensure the maintenance of homeostasis. Similarly, the primary function …

The nervous system detects and interprets a variety of chemical, mechanical, and thermal
stimuli. In the face of tissue injury, local inflammatory products perpetuate ongoing activity …

Physiological pain serves as a warning of exposure to danger and prompts us to withdraw
from noxious stimuli to prevent tissue damage. Pain can also alert us of an infection or organ …