During neonatal hypoxic–ischemic brain injury, activation of transcription of a series of
genes is induced to stimulate erythropoiesis, anti-apoptosis, apoptosis, necrosis and …

Hypoxia, which occurs in the brain when oxygen availability drops below the normal level, is
a major cause of perinatal hypoxic–ischemic injury (HII). The transcriptional factor hypoxia …

Hypoxia-inducible factor-1alpha (HIF-1α) has been considered as a regulator of both
prosurvival and prodeath pathways in the nervous system. The present study was designed …

Hypoxia inducible factor-1α (HIF-1α) plays an important role in maintaining oxygen
equilibrium. Pathologic conditions such as hypoxia or ischemia have been reported to cause …

Background Hypoxia-inducible-factor-1alpha (HIF-1α) has been considered as a regulator
of both prosurvival and prodeath pathways in the nervous system. This study was designed …

Evidence suggests that the activation of the transcription factor hypoxia-inducible factor 1α
(HIF-1α) may promote cell survival in hypoxic or ischemic brain. To help understand the role …

Abstract Hypoxia‐inducible factor‐1 (HIF‐1) is a heterodimer composed of HIF‐1α and HIF‐
1β protein subunits. This transcription factor is essential for the activation of hypoxia …

A divergence in the supply and consumption of oxygen in brain tissue initiates complex
cycle of biochemical and molecular events resulting in neuronal death. To overcome such …

Hypoxia-inducible transcription factors (HIF)-1 and HIF-2, composed of an oxygen-
dependent α-subunit and a constitutive β-subunit, have been characterized as the most …

Hypoxia inducible factor 1α (HIF-1α) is a key regulator of cellular oxygen homeostasis.
However, the regulation of HIF-1α in neonates with hypoxia–ischemia (HI) is not clear …