Extracellular Ca2+ Acts as a Mediator of Communication from Neurons to Glia

A Torres, F Wang, Q Xu, T Fujita, R Dobrowolski… - Science …, 2012 - science.org
Defining the pathways through which neurons and astrocytes communicate may contribute
to the elucidation of higher central nervous system functions. We investigated the possibility …

Astrocytes Modulate Neural Network Activity by Ca2+-Dependent Uptake of Extracellular K+

F Wang, NA Smith, Q Xu, T Fujita, A Baba… - Science …, 2012 - science.org
Astrocytes are electrically nonexcitable cells that display increases in cytosolic calcium ion
(Ca2+) in response to various neurotransmitters and neuromodulators. However, the …

Astrocyte Ca2+-evoked ATP release regulates myelinated axon excitability and conduction speed

J Lezmy, IL Arancibia-Cárcamo, T Quintela-López… - Science, 2021 - science.org
INTRODUCTION Astrocytes support neuronal function throughout the central nervous
system. In the gray matter, they regulate synapse number during development, remove …

Neural signalling: Neuromodulatory astrocytes

SJ Smith - Current Biology, 1994 - cell.com
Neural Signalling: Neuromodulatory astrocytes: Current Biology Skip to Main Content
Advertisement Current Biology This journal offers authors two options (open access or …

[HTML][HTML] Local resting Ca2+ controls the scale of astroglial Ca2+ signals

CM King, K Bohmbach, D Minge, A Delekate, K Zheng… - Cell reports, 2020 - cell.com
Astroglia regulate neurovascular coupling while engaging in signal exchange with neurons.
The underlying cellular machinery is thought to rely on astrocytic Ca 2+ signals, but what …

Neurone‐to‐astrocyte signalling in the brain represents a distinct multifunctional unit

T Fellin, G Carmignoto - The Journal of physiology, 2004 - Wiley Online Library
Astrocytes can respond to neurotransmitters released at the synapse by generating
elevations in intracellular Ca2+ concentration ([Ca2+] i) and releasing glutamate that signals …

Mechanisms of ATP‐and glutamate‐mediated calcium signaling in white matter astrocytes

N Hamilton, S Vayro, F Kirchhoff, A Verkhratsky… - Glia, 2008 - Wiley Online Library
Neurotransmitters released at synapses mediate Ca2+ signaling in astrocytes in CNS grey
matter. Here, we show that ATP and glutamate evoke these Ca2+ signals in white matter …

Local Ca2+ detection and modulation of synaptic release by astrocytes

MA Di Castro, J Chuquet, N Liaudet… - Nature …, 2011 - nature.com
Astrocytes communicate with synapses by means of intracellular calcium ([Ca2+] i)
elevations, but local calcium dynamics in astrocytic processes have never been thoroughly …

[HTML][HTML] Glial Ca2+signaling links endocytosis to K+ buffering around neuronal somas to regulate excitability

S Weiss, JE Melom, KG Ormerod, YV Zhang… - Elife, 2019 - elifesciences.org
Glial-neuronal signaling at synapses is widely studied, but how glia interact with neuronal
somas to regulate their activity is unclear. Drosophila cortex glia are restricted to brain …

Astrocyte calcium signaling: from observations to functions and the challenges therein

BS Khakh, KD McCarthy - Cold Spring Harbor …, 2015 - cshperspectives.cshlp.org
We provide an overview of recent progress on the study of astrocyte intracellular Ca2+
signaling. We consider the methods that have been used to monitor astrocyte Ca2+ signals …