Asthma is an intractable disease involving the infiltration of inflammatory cells and mucus
plugging. Despite small molecular mucolytics having the ability to break the disulfide bonds …

Neutrophilic asthma, as corticosteroid resistant asthma, is clinically more severe than
eosinophilic asthma. Therefore, the treatment of neutrophilic asthma has been a …

Background Acute lung injury (ALI), a severe health-threatening disease, has a risk of
causing chronic pulmonary fibrosis. Informative and powerful evidence suggests that …

Asthma is a serious global public health concern. Airway neutrophilic inflammation is closely
related to severe asthma, for which effective and safe therapies remain to be developed …

Abstract Allergic rhinitis (AR), histamine-mediated upper airway inflammatory disorder, is
characterized by sneezing, itching, airway hyperreactivity, etc. Though it is clinically well …

Mucus is a complex barrier for pharmacological treatments and overcoming it is one of the
major challenges faced during transmucosal drug delivery. To tackle this issue, a novel …

Airway mucus in cystic fibrosis (CF) is highly elastic, but the mechanism behind this
pathology is unclear. We hypothesized that the biophysical properties of CF mucus are …

Airway mucus is a complex viscoelastic gel that provides a defensive physical barrier and
shields the airway epithelium by trapping inhaled foreign pathogens and facilitating their …

The aim of this study was to improve the bioavailability of polymyxin B (PMB) in pulmonary
nebulized drug delivery. To this end, we developed a nano-delivery system that penetrates …

Multi-functionalized nanoparticles (NPs) have been extensively investigated for their
potential in household and commercial products, and biomedical applications. Previous …