Numerous extracellular proteins and glycosaminoglycans (GAG s) undergo limited
enzymatic cleavage resulting in the release of fragments exerting biological activities, which …

Controlled proteolysis of extracellular matrix components releases bioactive fragments or
unmasks cryptic sites that play key roles in controlling various physio-pathological …

The extracellular matrix (ECM) is a source of bioactive fragments called matricryptins or
matrikines resulting from the proteolytic cleavage of extracellular proteins (eg, collagens …

The term “matrikines” was coined for designating peptides liberated by partial proteolysis of
extracellular matrix macromolecules, which are able to regulate cell activities. Among these …

Alterations in the composition of the extracellular matrix (ECM) critically regulate the cellular
responses in tissue repair, remodeling, and fibrosis. After injury, proteolytic degradation of …

Dermatologists are faced daily with the need to optimize skin repair and excise cutaneous
cancers. The extracellular matrix plays a pivotal role in cellular migration, proliferation, and …

The term of “matrikines” was coined for designating peptides liberated by partial proteolysis
of extracellular matrix macromolecules, which are able to regulate cell activities. Among …

Background Tumor microenvironment is a complex system composed of a largely altered
extracellular matrix with different cell types that determine angiogenic responses and tumor …

The extracellular matrix is comprised of 1100 core-matrisome and matrisome-associated
proteins and of glycosaminoglycans. This structural scaffold contributes to the organization …

Extracellular matrix has been known for a long time as an architectural support for the
tissues. Many recent data, however, have shown that extracellular matrix macromolecules …