Central nervous system leukemia (CNS-L) is caused by leukemic cells infiltrating into the
meninges or brain parenchyma and remains the main reason for disease relapse. Currently …

Introduction Integrin αvβ6, which is upregulated in malignancies and remains absent or
weak in normal tissue, is a promising target in molecular imaging therapeutics. In vivo …

Integrins, particularly the αvβ3 heterodimers, play important roles in tumor-induced
angiogenesis and invasiveness. To image the expression pattern of the αvβ3 integrin in …

Background The motif RXDLXXL-based nanoprobes allow specific imaging of integrin αvβ6,
a protein overexpressed during tumorigenesis and tumor progression of various tumors. We …

Purpose: To investigate the targeting activity of the peptide (named P1c) derived from
connective tissue growth factor (CTGF) to αvβ3‐rich tumor cells. Materials and Methods: P1c …

Here, we propose a zwitterionic near-infrared (NIR) fluorophore–tryptophan (Trp) conjugate
with a cleavable linker as a minimal-sized versatile platform (MP) for the preparation of …

Purpose The purpose of this study was to develop and evaluate two α v β 6-targeted
fluorescent imaging agents. The integrin subtype α v β 6 is significantly upregulated in a …

Objective The aim of the present study was to develop potential candidates of integrin αvβ3-
targeted imaging agent, which can facilitate the diagnosis and treatment of malignant solid …

Integrin α6 has been considered a promising biomarker, is overexpressed in many tumors,
and plays a vital role in tumor formation, recurrence, and metastasis. In this study, we …

Radiolabeled cyclic arginine-glycine-aspartic (RGD) peptides can be used for noninvasive
determination of integrin αvβ3 expression in tumors. In this study, we performed …