Aryl hydrocarbon receptor–independent toxicity of weathered crude oil during fish development

JP Incardona, MG Carls, H Teraoka… - Environmental …, 2005 - ehp.niehs.nih.gov
Polycyclic aromatic hydrocarbons (PAHs), derived largely from fossil fuels and their
combustion, are pervasive contaminants in rivers, lakes, and nearshore marine habitats …

Synergistic induction of AHR regulated genes in developmental toxicity from co-exposure to two model PAHs in zebrafish

AR Timme-Laragy, CJ Cockman, CW Matson… - Aquatic toxicology, 2007 - Elsevier
Polycyclic aromatic hydrocarbons (PAHs) are pollutants created by the incomplete
combustion of carbon, and are increasing in the environment largely due to the burning of …

AHR2 knockdown prevents PAH-mediated cardiac toxicity and XRE-and ARE-associated gene induction in zebrafish (Danio rerio)

LA Van Tiem, RT Di Giulio - Toxicology and applied pharmacology, 2011 - Elsevier
Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous environmental contaminants often
present in aquatic systems as complex mixtures. Embryonic fish are sensitive to the …

Defects in cardiac function precede morphological abnormalities in fish embryos exposed to polycyclic aromatic hydrocarbons

JP Incardona, TK Collier, NL Scholz - Toxicology and applied …, 2004 - Elsevier
Fish embryos exposed to complex mixtures of polycyclic aromatic hydrocarbons (PAHs) from
petrogenic sources show a characteristic suite of abnormalities, including cardiac …

Structurally distinct polycyclic aromatic hydrocarbons induce differential transcriptional responses in developing zebrafish

BC Goodale, SC Tilton, MM Corvi, GR Wilson… - Toxicology and applied …, 2013 - Elsevier
Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous in the environment as components
of fossil fuels and by-products of combustion. These multi-ring chemicals differentially …

Geologically distinct crude oils cause a common cardiotoxicity syndrome in developing zebrafish

JH Jung, CE Hicken, D Boyd, BF Anulacion, MG Carls… - Chemosphere, 2013 - Elsevier
Crude oils from different geological formations vary in composition, yet most crude oils
contain a polycyclic aromatic hydrocarbon (PAH) fraction that would be expected to produce …

The role of the aryl hydrocarbon receptor pathway in mediating synergistic developmental toxicity of polycyclic aromatic hydrocarbons to zebrafish

SM Billiard, AR Timme-Laragy… - Toxicological …, 2006 - academic.oup.com
Planar halogenated aromatic hydrocarbons (pHAHs), such as 2, 3, 7, 8-tetrachlorodibenzo-p-
dioxin (dioxin), show strong binding affinity for the aryl hydrocarbon receptor (AHR) and are …

Long-term effects of crude oil on developing fish: lessons from the Exxon Valdez oil spill

J Short - Energy Sources, 2003 - Taylor & Francis
Habitat damage resulting from oil contamination is underestimated by acute toxicity assays.
Nearshore substrates oiled by spills may become persistent pollution sources of toxic …

Characterizing crude oil toxicity to early-life stage fish based on a complex mixture: are we making unsupported assumptions?

JP Meador, J Nahrgang - Environmental science & technology, 2019 - ACS Publications
Numerous studies of the water-soluble fraction (WSF) from crude oil have concluded that
polycyclic aromatic hydrocarbons (PAHs) are the primary causative agents for early life …

Molecular mechanisms of crude oil developmental toxicity in fish

JP Incardona - Archives of Environmental Contamination and …, 2017 - Springer
With major oil spills in Korea, the United States, and China in the past decade, there has
been a dramatic increase in the number of studies characterizing the developmental toxicity …