Peripheral nerve injury activates satellite cells to produce interleukin 1β (IL-1β) which
mediates inflammation and hyperalgesia. This study investigated the hypothesis that …

The present study investigated whether under in vivo conditions, inflammation alters the
excitability of nociceptive Aδ-trigeminal ganglion (TRG) neurons innervating the facial skin …

The glial cytokine, interleukin-1β (IL-1β), potentiates the excitability of nociceptive trigeminal
ganglion (TRG) neurons via membrane depolarization following peripheral inflammation …

There is a growing body of evidence that cytokines contribute to both induction and
maintenance of neuropathic pain derived from changes in dorsal root ganglia (DRG) …

Background: Glial cells have been shown to directly participate to the genesis and
maintenance of chronic pain in both the sensory ganglia and the central nervous system …

Neurons in dorsal root ganglia (DRG) are surrounded by an envelope of satellite glial cells
(SGCs). Little is known about SGC physiology and their interactions with neurons. In this …

Responses resulting from injury to the trigeminal nerve exhibit differences compared with
those caused by lesion of other peripheral nerves. With the aim of elucidating the …

Peripheral inflammation induces central sensitization characterized by the development of
allodynia and hyperalgesia to mechanical and thermal stimuli. Recent evidence suggests …

Background Accidental mandibular nerve injury may occur during tooth extraction or implant
procedures, causing ectopic orofacial pain. The exact mechanisms underlying ectopic …

Peripheral tissue inflammation can alter the properties of somatic sensory pathways,
causing behavioral hypersensitivity and resulting in increased responses to pain caused by …